Anti-Mouse CD29 Purified

Description: The KMI6 monoclonal antibody reacts with mouse CD29 (integrin β1), a 120-130 kDa member of the β integrin family expressed by leukocytes, endothelial, smooth muscle and epithelial cells. CD29 binds non-covalently with the α integrins CD49a-f, to form the VLA-1 through VLA-6 complexes, respectively, and also with CD51. These αβ integrin heterodimers are capable of mediating a variety of cellular responses including adhesion, trafficking, proliferaton and differentiation. All of the integrins which include CD29 bind to extracellular matrix proteins including collagen, laminin, fibronectin and vitronectin, whereas some CD29-containing integrins also interact with cellular receptors including VCAM-1 and MadCAM-1. The KMI6 antibody has been shown to be an activating antibody for β1 integrins, enhancing lymphocyte binding to fibronectin.

References: Aoyama K, Oritani K, Yokota T, Ishikawa J, Nishiura T, Miyake K, Kanakura Y, Tomiyama Y, Kincade PW, Matsuzawa Y. Stromal cell CD9 regulates differentiation of hematopoietic stem/progenitor cells. Blood. 1999 Apr 15;93(8):2586-94. (KMI6, IP, WB, PubMed)

Wadsworth SA, Chang AC, Hong MJ, Halvorson MJ, Otto S, Coligan JE. Expression of a novel integrin beta1 chain epitope and anti-beta1 antibody-mediated enhancement of fibronectin binding are dependent on the stage of T cell differentiation. J Immunol. 1995 Mar 1;154(5):2125-33. (KMI6, FC, IP, FA, PubMed)

Jacobsen K, Miyake K, Kincade PW, Osmond DG. Highly restricted expression of a stromal cell determinant in mouse bone marrow in vivo. J Exp Med. 1992 Oct 1;176(4):927-35. (KMI6, IP, PubMed)