Anti-Mouse CD282 (TLR2) Biotin

Description: The 6C2 monoclonal antibody reacts with mouse Toll-like receptor 2 (TLR2). Mouse TLR2 is expressed by the myeloid lineage, including macrophage and dendritic cells in splenocytes and the RAW264.7 cell line. To date, at least twelve members of the Toll family have been identified in human and mouse. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR2 is expressed on the surface of cells and is responsible for distinguishing different pathogens.

References: Gibson FC 3rd, Hong C, Chou HH, Yumoto H, Chen J, Lien E, Wong J, Genco CA. 2004. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation. 109(22):2801-6.

Paterson HM, Murphy TJ, Purcell EJ, Shelley O, Kriynovich SJ, Lien E, Mannick JA, Lederer JA. Injury Primes the Innate Immune System for Enhanced Toll-Like Receptor Reactivity. J Immunol. 2003 Aug 1;171(3):1473-1483.

Nilsen NJ, Nonstad U, Khan N, Knetter CF, Akira S, Sundan A, Espevik T, Lien E. 2004. Lipopolysaccharide and double-stranded RNA upregulate toll-like receptor 2 independently of myeloid differentiation factor 88. J Biol Chem. 279(38):39727-35.

Frasnelli ME, Tarussio D, et al. 2005. TLR2 modulates inflammation in zymosan-induced arthritis in mice. Arthritis Res Ther. 7(2):R370-9. (6C2, IHC frozen, PubMed)

Ziegler G, Harhausen D, et al. 2007. TLR2 has a detrimental role in mouse transient focal cerebral ischemia. Biochem Biophys Res Commun. 359(3):574-9. (6C2, IHC frozen, PubMed)

Hoffmann O, Braun JS, et al. 2007. TLR2 mediates neuroinflammation and neuronal damage. J Immunol. 15;178(10):6476-81. (6C2, ICC, PubMed)