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  • Anti-Mouse CD282 (TLR2) Alexa Fluor® 647 (To Be Discontinued. Refer to Cat. No. 50-9021)

Anti-Mouse CD282 (TLR2) Alexa Fluor® 647 (To Be Discontinued. Refer to Cat. No. 50-9021)

Also known as: TLR-2, toll-like receptor 2

Clone: 6C2

RUO: For Research Use Only. Not for use in diagnostic procedures.

Attention: Replacement format is eFluor 660. Select Cat. No. 50-9021.

SKU# 51-9021

Cat. No. Size
51-9021-80 25 ug
51-9021-82 100 ug
Please inquire about custom configurations or bulk packaging.

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Data for Anti-Mouse CD282 (TLR2) Alexa Fluor® 647.

Staining of BALB/c splenocytes with Anti-Mouse CD11b PE (cat. 12-0112) and 0.06 ug of Rat IgG2b...View More

  • Data for Anti-Mouse CD282 (TLR2) Alexa Fluor® 647.
Description

Description: The 6C2 monoclonal antibody reacts with mouse Toll-like receptor 2 (TLR2). Mouse TLR2 is expressed by the myeloid lineage, including macrophage and dendritic cells in splenocytes and the RAW264.7 cell line. To date, at least twelve members of the Toll family have been identified in human and mouse. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR2 is expressed on the surface of cells and is responsible for distinguishing different pathogens.

Details
Host Rat
Isotype IgG2b, kappa
Reactivity Mouse
Conjugate Alexa Fluor 647
Laser Red Laser
Emit 668 nm
Excite 633 nm
Legal Alexa Fluor® and Pacific Blue® are registered trademarks of and licensed under patents assigned to Molecular Probes, Inc. for research use only. This product is subject to an agreement between Molecular Probes, Inc. and eBioscience, and the manufacture, use, sale or import of this product may be subject to one or more U.S. patents, pending applications and corresponding foreign equivalents, owned by Molecular Probes, Inc. (a wholly owned subsidiary of Invitrogen Corp). The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product for life science research or as an ASR. The buyer cannot use this product for manufacturing or for any other screening (specifically including use in combination with microarrays or High Content Screening) or testing purpose, other than as an ASR. For information on purchasing a license to this product for purposes other than life science research or use as an ASR, contact Molecular Probes, Inc.
Reported Applications Flow Cytometric Analysis
Documentation

For complete product information, please download the TDS or IFU document.

TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
13-9021 Anti-Mouse CD282 (TLR2) Biotin FC, IHC RUO
50-9021 Anti-Mouse CD282 (TLR2) eFluor® 660 (Alexa Fluor® 647 Replacement) 633 nm 668 nm FC RUO
14-9021 Anti-Mouse CD282 (TLR2) Purified FC, IHC, IP RUO
12-9021 Anti-Mouse CD282 (TLR2) PE 488 - 561 nm 575 nm FC RUO
16-9021 Anti-Mouse CD282 (TLR2) Functional Grade Purified FC RUO
11-9021 Anti-Mouse CD282 (TLR2) FITC 488 nm 518 nm FC RUO
References

References: Gibson FC 3rd, Hong C, Chou HH, Yumoto H, Chen J, Lien E, Wong J, Genco CA. 2004. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation. 109(22):2801-6.

Paterson HM, Murphy TJ, Purcell EJ, Shelley O, Kriynovich SJ, Lien E, Mannick JA, Lederer JA. Injury Primes the Innate Immune System for Enhanced Toll-Like Receptor Reactivity. J Immunol. 2003 Aug 1;171(3):1473-1483.

Nilsen NJ, Nonstad U, Khan N, Knetter CF, Akira S, Sundan A, Espevik T, Lien E. 2004. Lipopolysaccharide and double-stranded RNA upregulate toll-like receptor 2 independently of myeloid differentiation factor 88. J Biol Chem. 279(38):39727-35.

Frasnelli ME, Tarussio D, et al. 2005. TLR2 modulates inflammation in zymosan-induced arthritis in mice. Arthritis Res Ther. 7(2):R370-9. (6C2, IHC frozen, PubMed)

Ziegler G, Harhausen D, et al. 2007. TLR2 has a detrimental role in mouse transient focal cerebral ischemia. Biochem Biophys Res Commun. 359(3):574-9. (6C2, IHC frozen, PubMed)

Hoffmann O, Braun JS, et al. 2007. TLR2 mediates neuroinflammation and neuronal damage. J Immunol. 15;178(10):6476-81. (6C2, ICC, PubMed)

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