Anti-Mouse CD28 PE-Cyanine7

Also known as: Tp44

Clone: 37.51

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 25-0281

Cat. No.	Size
25-0281-81	50 ug
25-0281-82	100 ug
Please inquire about custom configurations or bulk packaging.

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Staining of BALB/c splenocytes with Anti-Mouse CD3e FITC (cat. 11-0031) and 0.5 ug of Golden Syrian...View More

Description

Description: The 37.51 monoclonal antibody reacts with the mouse CD28 molecule, a 45 kDa homodimer expressed by thymocytes, mature T cells and NK cells. CD28 is a ligand for CD80 (B7-1) and CD86 (B7-2) and is a potent costimulator of T cells. Signaling through CD28 augments IL-2 and IL-2 receptor expression as well as cytotoxicity of CD3-activated T cells.

Details

Host	Golden Syrian Hamster
Isotype	IgG
Reactivity	Mouse
Conjugate	PE-Cyanine7
Laser	Blue Laser, Green Laser, Yellow-Green Laser
Emit	775 nm
Excite	488 - 561 nm
Legal	FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT # 5,268,486, 5,569,587 AND 5,627,027 AND FOREIGN EQUIVALENTS AND PENDING APPLICATIONS. THIS MATERIAL IS SUBJECT TO PROPRIETARY RIGHTS OF GE HEALTHCARE BIO-SCIENCES CORP. AND CARNEGIE MELLON UNIVERSITY AND MADE AND SOLD UNDER LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. THIS PRODUCT IS LICENSED FOR SALE ONLY FOR RESEARCH. IT IS NOT LICENSED FOR ANY OTHER USE. THERE IS NO IMPLIED LICENSE HEREUNDER FOR ANY COMMERCIAL USE. COMMERCIAL USE shall include: 1. sale, lease, license or other transfer of the material or any material derived or produced from it; 2. sale, lease, license or other grant of rights to use this Material or any material derived or produced from it; 3. use of this material to perform services for a fee for third parties. IF YOU REQUIRE A COMMERCIAL LICENSE TO USE THIS MATERIAL AND DO NOT HAVE ONE, RETURN THIS MATERIAL, UNOPENED TO EBIOSCIENCE, INC. 10255 SCIENCE CENTER DRIVE, SAN DIEGO, CALIFORNIA 92121 USA AND ANY MONEY PAID FOR THE MATERIAL WILL BE REFUNDED.
Reported Applications	Flow Cytometric Analysis

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
17-0281	Anti-Mouse CD28 APC	633 - 647 nm	660 nm	FC	RUO
14-0281	Anti-Mouse CD28 Purified			FC, IHC, FA, IP	RUO
12-0281	Anti-Mouse CD28 PE	488 - 561 nm	575 nm	FC	RUO
45-0281	Anti-Mouse CD28 PerCP-Cyanine5.5	488 nm		FC	RUO
16-0281	Anti-Mouse CD28 Functional Grade Purified			FC, FA	RUO
13-0281	Anti-Mouse CD28 Biotin			FC	RUO
15-0281	Anti-Mouse CD28 PE-Cyanine5	488 - 561 nm		FC	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
11-0031	Anti-Mouse CD3e FITC	488 nm		FC	RUO
25-0289	Anti-Human CD28 PE-Cyanine7	488 - 561 nm	775 nm	FC	RUO
25-4914	Golden Syrian Hamster IgG Isotype Control PE-Cyanine7	488 - 561 nm	775 nm	FC	RUO

References

References: Nandi, D., J. A. Gross, et al. (1994). CD28-mediated costimulation is necessary for optimal proliferation of murine NK cells. J Immunol 152(7): 3361-9.

Gross, J. A., E. Callas, et al. (1992). Identification and distribution of the costimulatory receptor CD28 in the mouse. J Immunol 149(2): 380-8.

Harding, F. A., J. G. McArthur, et al. (1992). CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356(6370): 607-9.

Gross, J. A., T. St. John, et al. (1990). The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression. J Immunol 144(8): 3201-10.

View More Products

Antigens	Area of Biology	Cell Type	Formats
CD28	Adaptive Immunity Cell Signaling	T Cells	PE-Cyanine7