Anti-Mouse CD28 Functional Grade Purified

Description: The 37.51 monoclonal antibody reacts with the mouse CD28 molecule, a 45 kDa homodimer expressed by thymocytes, mature T cells and NK cells. CD28 is a ligand for CD80 (B7-1) and CD86 (B7-2) and is a potent costimulator of T cells. Signaling through CD28 augments IL-2 and IL-2 receptor expression as well as cytotoxicity of CD3-activated T cells.

References:
Nandi, D., J. A. Gross, et al. (1994). "CD28-mediated costimulation is necessary for optimal proliferation of murine NK cells." J Immunol 152(7): 3361-9.
Gross, J. A., E. Callas, et al. (1992). "Identification and distribution of the costimulatory receptor CD28 in the mouse." J Immunol 149(2): 380-8.
Harding, F. A., J. G. McArthur, et al. (1992). "CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones." Nature 356(6370): 607-9.
Gross, J. A., T. St. John, et al. (1990). "The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression." J Immunol 144(8): 3201-10.