Anti-Mouse CD253 (TRAIL) PE

Description: The N2B2 monoclonal antibody reacts with mouse TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily. TRAIL is not detected on the surface of freshly isolated T, B, or NK cells, but can be induced preferentially on CD3^- NK1.1⁺ NK cells after stimulation with IL-2 or IL-15. N2B2 inhibits IL-2- or IL-15-activated NK cell cytotoxicity against mouse fibrosarcoma L929 target cells.

References: Kayagaki, N., N. Yamaguchi, et al. (1999). Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells. J Immunol 163(4): 1906-13.

Hayakawa Y, Screpanti V, Yagita H, Grandien A, Ljunggren HG, Smyth MJ, Chambers BJ.NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy.J Immunol. 2004 Jan 1;172(1):123-9. (PubMed FA in vivo)

Taieb J, Chaput N, et al. A novel dendritic cell subset involved in tumor immunosurveillance.Nat Med. 2006 Feb;12(2):214-9. (PubMed FA in vivo)