Anti-Mouse CD229 (Ly-9) APC

Description: This Ly9ab3 monoclonal antibody reacts with mouse CD229 (also known as Ly9), an approximately 120-kDa member of the Signaling Lymphocyte Activation Molecule (SLAM) immunoglobulin superfamily. This type I transmembrane glycoprotein is expressed on a variety of immune cell types, including thymocytes, hematopoietic stem cells, macrophages, T and B lymphocytes, regulatory T cells, and natural killer cells. CD229 has been shown to interact with the adaptor proteins SLAM-associated protein (SAP) and EAT-2. This antibody recognizes both Ly9 alleles, Ly9.1 and Ly9.2.

References: Sintes J, Romero X, Marin P, Terhorst C, Engel P. Differential expression of CD150 (SLAM) family receptors by human hematopoietic stem and progenitor cells. 2008 Sep; 36(9): 1199-204.

Sintes J, Vidal-Laliena M, Romero X, Tovar V, Engel P. Characterization of mouse CD229 (Ly9), a leukocyte cell surface molecule of the CD150 family. Tissue Antigens. 2007 Nov; 70(5): 355-62. (Ly9ab3, FC, Pubmed)

Graham DB, Bell MP, McCausland MM, Huntoon CJ, van Deursen J, Faubion WA, Crotty S, McKean DJ. (CD229)-deficient mice exhibit T cells defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient mice. J. Immunol. 2006 Jan 1; 176(1): 291-300.