Anti-Mouse CD213a1 (IL-13 Receptor alpha 1) PE

Description: The 13MOKA monoclonal antibody reacts with mouse CD213 alpha 1 (interleukin-13 receptor alpha 1, IL-13Ra1). CD213a1 is the low-affinity IL-13 receptor which mediates normal IL-13 inflammatory signaling. It has been shown that CD213a1 binds to IL-13 which then recruits CD124 (IL-4Rα) to stabilize the low-affinity interaction and form the active signaling complex. The CD213a1/CD124 complex can also serve as a receptor for IL-4, although the role of CD213a1 in this complex is poorly understood. CD213a1 is expressed on activated B and T cells and other cells.

References: Newcomb DC, Zhou W, Moore ML, Goleniewska K, Hershey GK, Kolls JK, Peebles RS Jr. A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production. J Immunol. 2009 May 1;182(9):5317-21.

Munitz A, Brandt EB, Mingler M, Finkelman FD, Rothenberg ME. Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7240-5.

LaPorte SL, Juo ZS, Vaclavikova J, Colf LA, Qi X, Heller NM, Keegan AD, Garcia KC. Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. Cell. 2008 Jan 25;132(2):259-72.

Hajoui O, Zheng H, Guay J, Letuve S, Fawaz LM, Mazer BD. Regulation of IL-13 receptor alpha 1 expression and signaling on human tonsillar B-lymphocyte subsets. J Allergy Clin Immunol. 2007 Dec;120(6):1425-32.