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Anti-Mouse CD213a1 (IL-13 Receptor alpha 1) PE

Also known as: IL-13Ra1

Clone: 13MOKA

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 12-2130

Cat. No. Size
12-2130-80 25 ug
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Data for Anti-Mouse CD213a1 (IL-13 Receptor alpha 1) PE.

Splenocytes were cultured and stimulated with Anti-Mouse CD3 and Anti-Mouse CD28 for 3 days or...View More

  • Data for Anti-Mouse CD213a1 (IL-13 Receptor alpha 1) PE.
Description

Description: The 13MOKA monoclonal antibody reacts with mouse CD213 alpha 1 (interleukin-13 receptor alpha 1, IL-13Ra1). CD213a1 is the low-affinity IL-13 receptor which mediates normal IL-13 inflammatory signaling. It has been shown that CD213a1 binds to IL-13 which then recruits CD124 (IL-4Rα) to stabilize the low-affinity interaction and form the active signaling complex. The CD213a1/CD124 complex can also serve as a receptor for IL-4, although the role of CD213a1 in this complex is poorly understood. CD213a1 is expressed on activated B and T cells and other cells.

Details
Host Rat
Isotype IgG2a, kappa
Reactivity Mouse
Conjugate PE
Laser Blue Laser, Green Laser, Yellow-Green Laser
Emit 578 nm
Excite 488 - 561 nm
Reported Applications Flow Cytometric Analysis
Documentation
TDS Link Download TDS
Related Products
Cat. No. Name Excite Emit Application Reg.
12-4321 Rat IgG2a K Isotype Control PE 488 - 561 nm 578 nm FC RUO
16-0281 Anti-Mouse CD28 Functional Grade Purified FC, FA RUO
11-0042 Anti-Mouse CD4 FITC 488 nm 520 nm FC RUO
16-0031 Anti-Mouse CD3e Functional Grade Purified FC, FA RUO
References

References: Newcomb DC, Zhou W, Moore ML, Goleniewska K, Hershey GK, Kolls JK, Peebles RS Jr. A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production. J Immunol. 2009 May 1;182(9):5317-21.

Munitz A, Brandt EB, Mingler M, Finkelman FD, Rothenberg ME. Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7240-5.

LaPorte SL, Juo ZS, Vaclavikova J, Colf LA, Qi X, Heller NM, Keegan AD, Garcia KC. Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. Cell. 2008 Jan 25;132(2):259-72.

Hajoui O, Zheng H, Guay J, Letuve S, Fawaz LM, Mazer BD. Regulation of IL-13 receptor alpha 1 expression and signaling on human tonsillar B-lymphocyte subsets. J Allergy Clin Immunol. 2007 Dec;120(6):1425-32.


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