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Anti-Mouse CD205 Super Bright 436

Also known as: DEC-205, Ly75

Clone: 205yekta

RUO: For Research Use Only. Not for use in diagnostic procedures.

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SKU# 62-2051

Cat. No. Size
62-2051-80 25 ug
62-2051-82 100 ug

Data for Anti-Mouse CD205 Super Bright 436.

Staining of mouse bone marrow cells with Anti-Mouse Ly-6G (Gr-1) APC (cat. 17-5931) and 0.015 ug of...View More

  • Data for Anti-Mouse CD205 Super Bright 436.
Description

Description: The 205yekta antibody reacts with mouse CD205, also known as DEC-205 (dendritic and epithelial cells, 205 kDa). CD205 is an integral membrane glycoprotein involved in antigen uptake, trafficking and presentation that improves the induction of antigen-specific T cell immunity. CD205 is highly expressed by CD8+ dendritic cells (DCs) and also expressed at different levels by bone marrow Gr1+ cells, Langerhans cells, (BMDC) bone marrow derived DCs and thymic epithelial cells.

CD205 has been shown to bind to PE-Cy5.5 antibody and streptavidin conjugates; therefore, this format should not be used on CD205+ dendritic cells.

Details
Host Rat
Isotype IgG2a, kappa
Reactivity Mouse
Conjugate Super Bright 436
Laser Violet Laser
Emit 436 nm
Excite 405 nm
Legal Patent pending.
Reported Applications Flow Cytometric Analysis
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
25-2051 Anti-Mouse CD205 PE-Cyanine7 488 - 561 nm 775 nm FC RUO
53-2051 Anti-Mouse CD205 Alexa Fluor® 488 488 nm 519 nm FC RUO
12-2051 Anti-Mouse CD205 PE 488 - 561 nm 578 nm FC RUO
46-2051 Anti-Mouse CD205 PerCP-eFluor® 710 488 nm 710 nm FC RUO
13-2051 Anti-Mouse CD205 Biotin FC RUO
17-2051 Anti-Mouse CD205 APC 633 - 647 nm 660 nm FC RUO
61-2051 Anti-Mouse CD205 PE-eFluor® 610 488 - 561 nm 607 nm FC RUO
Related Products
Cat. No. Name Excite Emit Application Reg.
62-4321 Rat IgG2a K Isotype Control Super Bright 436 405 nm 436 nm FC RUO
17-5931 Anti-Mouse Ly-6G (Gr-1) APC 633 - 647 nm 660 nm FC RUO
SB-4400 Super Bright Staining Buffer FC GPR
References

References: Park CG, Rodriguez A, Steinman RM. PE-Cy5.5 conjugates bind to the cells expressing mouse DEC205/CD205. J Immunol Methods. 2012 Oct 31;384(1-2):184-90.

Bonifaz LC, Bonnyay DP, Charalambous A, Darguste DI, Fujii S, Soares H, Brimnes MK, Moltedo B, Moran TM, Steinman RM. In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination. J Exp Med. 2004 Mar 15;199(6):815-24.

Swiggard WJ, Mirza A, Nussenzweig MC, Steinman RM. DEC-205, a 205-kDa protein abundant on mouse dendritic cells and thymic epithelium that is detected by the monoclonal antibody NLDC-145: purification, characterization, and N-terminal amino acid sequence. Cell Immunol. 1995 Oct 15;165(2):302-11.

Witmer-Pack MD, Swiggard WJ, Mirza A, Inaba K, Steinman RM. Tissue distribution of the DEC-205 protein that is detected by the monoclonal antibody NLDC-145. II. Expression in situ in lymphoid and nonlymphoid tissues. Cell Immunol. 1995 Jun;163(1):157-62.

Inaba K, Swiggard WJ, Inaba M, Meltzer J, Mirza A, Sasagawa T, Nussenzweig MC, Steinman RM.Tissue distribution of the DEC-205 protein that is detected by the monoclonal antibody NLDC-145. I. Expression on dendritic cells and other subsets of mouse leukocytes. Cell Immunol. 1995 Jun;163(1):148-56.

Kraal G, Breel M, Janse M, Bruin G. Langerhans' cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody. J Exp Med. 1986 Apr 1;163(4):981-97.


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