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Anti-Mouse CD204 PE

Also known as: Macrophage Scavenger Receptor 1, MSR1, Scavenger Receptor Type A, SR-A

Clone: M204PA

RUO: For Research Use Only. Not for use in diagnostic procedures.

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SKU# 12-2046

Cat. No. Size
12-2046-80 25 ug
12-2046-82 100 ug

Data for Anti-Mouse CD204 PE.

Staining of BALB/c resident peritoneal exudate cells with Anti-Mouse F4/80 Antigen APC (cat....View More

  • Data for Anti-Mouse CD204 PE.
Description

Description: This M204PA antibody recognizes mouse CD204 also known as Macrophage Scavenger Receptor 1 (MSR 1), Scavenger Receptor A (SR-A) or SCARA1. CD204 belongs to the class A family of scavenger receptors that are primarily responsible for binding a wide variety of macromolecules and are involved in many aspects of macrophage activity. Other members of this family include: MARCO (SCARA2), CSR (SCARA3), SRCL (SCARA4) and SCARA5. All class A scavenger receptors are trans-membrane proteins with extracellular C-termini and homotrimeric structures. CD204 exists as 2 splice variants: the more ubiquitous full length isoform (type I) and a shorter isoform (type II) that lacks the C-terminal cysteine-rich domain. Both types are functional and bind modified LDL with similar affinity. In addition to lipid metabolism, CD204 plays an important role suppressing inflammation and macrophage activation. CD204 is considered one of the markers of M2 and Tumor-Associated Macrophages. Interestingly, this molecule is responsible for adherence of RAW264.7 cells to tissue culture-treated plastic in the absence of Ca and Mg cations.

This M204PA antibody binds to CD204 of multiple mouse strains, including C57Bl/6, Balb/c and Swiss-Webster (outbred). This antibody works on fixed cells and can be used to stain CD204 intracellularly. The M204PA antibody does not cross-react with human or rat. This antibody is not suitable for IHC staining.

Details
Host Rat
Isotype IgG2a, kappa
Reactivity Mouse
Conjugate PE
Laser Blue Laser, Green Laser, Yellow-Green Laser
Emit 578 nm
Excite 488 - 561 nm
Reported Applications Flow Cytometric Analysis
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
25-2046 Anti-Mouse CD204 PE-Cyanine7 488 - 561 nm 775 nm FC RUO
Related Products
Cat. No. Name Excite Emit Application Reg.
17-4801 Anti-Mouse F4/80 Antigen APC 633 - 647 nm 660 nm FC RUO
12-4321 Rat IgG2a K Isotype Control PE 488 - 561 nm 578 nm FC RUO
References

References: Kelley JL, Ozment TR, Li C, Schweitzer JB, Williams DL. Scavenger receptor-A (CD204): a two-edged sword in health and disease. Crit Rev Immunol.2014;34(3):241-61.

Prabhudas M, Bowdish D, Drickamer K, Febbraio M, Herz J, Kobzik L, Krieger M, Loike J, Means TK, Moestrup SK, Post S, Sawamura T, Silverstein S, Wang XY, El Khoury J. Standardizing scavenger receptor nomenclature. J Immunol. 2014 Mar 1;192(5):1997-2006.

Krieger M. The other side of scavenger receptors: pattern recognition for host defense. Curr Opin Lipidol. 1997 Oct;8(5):275-80.

Kodama T, Freeman M, Rohrer L, Zabrecky J, Matsudaira P, Krieger M. Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Nature. 1990 Feb 8;343(6258):531-5.

Goldstein JL, Ho YK, Basu SK, Brown MS. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci U S A. 1979 Jan;76(1):333-7.


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