Anti-Mouse CD1d Purified

Description: The 1B1 monoclonal antibody reacts with mouse CD1d, a 48 kDa glycoprotein with structural homology to MHC class I molecules. While similar to MHC Class I, CD1d associates with β2-m, functionally CD1d is similar to MHC Class II. 1B1 detects CD1d at varying levels on mouse leukocytes. 1B1 detects β2-m associated CD1d.

References:
Brossay L, D.Jullien, S. Cardell, B.C. Sydora, N. Burdin, R.L. Modlin, and M. Kronenberg. 1997. Mouse CD1 is mainly expressed on hemopoietic derived cells. J. Immunol. 159: 1216-1224.
Amano M., N. Baumgarth, M.D. Dick, L. Brossay, M. Kronenberg, L.A. Herzenberg, and S Strober. 1998. CD1 expression defines subsets of follicular and marginal zone B cells in the spleen: beta2-microglobulin-dependent and independent forms. J. Immunol. 161:1710-1717.
Sydora B.C., L. Brossay, A. Hagenbaugh, M. Kronenberg, and H. Cheroutre. 1996. TAP-independent selection of CD8+ intestinal intraepithelial lymphocytes. J. Immunol. 156: 4209-4216.
Roark J.H., S.-H. Park, J. Jayawardena, U. Kavita, M. Shannon, and A. Bendelac. 1998. CD1.1 expression by mouse antigen-presenting cells and marginal zone B cells. J. Immunol. 160: 3121-3127.
Kawano, T. J. Cui, Y. Koezuka, I. Toura, Y. Kaneko, K. Motoki, H. Ueno, R. Nakagawa, H. Sato, E. Kondo, H. Koseki, and M. Taniguchi. 1997. CD1d-restricted and TCR-mediated activation of Valpha14 NKT cells by glycosylceramides. Science 278:1626-1629.
Brudin N., L. Brossay, Y. Koezuka, S. T. Smiley, M. J. Grusby, M. Gui, M. Taniguchi, K. Hayakawa, M. Kronenberg. 1998. Selective Ability of Mouse CD1 to Present Glycolipids: alpha-Galactosylceramide Specifically Stimulates Valpha14+ NK T Lymphocytes. J. Immunol 161: 271-81.
Szalay G, Ladel CH, Blum C, Brossay L, Kronenberg M, Kaufmann SH. Cutting edge: anti-CD1 monoclonal antibody treatment reverses the production patterns of TGF-beta 2 and Th1 cytokines and ameliorates listeriosis in mice. J Immunol. 1999 Jun 15;162(12):6955-8. (in vivo, PubMed)