Anti-Mouse CD1d Alexa Fluor® 488

Also known as: CD1.1, Ly-38

Clone: 1B1

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 53-0011

Cat. No.	Size
53-0011-80	25 ug
53-0011-82	100 ug

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Description

Description: The 1B1 monoclonal antibody reacts with mouse CD1d, a 48 kDa glycoprotein with structural homology to MHC class I molecules. While similar to MHC Class I, CD1d associates with β2-m, functionally CD1d is similar to MHC Class II. 1B1 detects CD1d at varying levels on mouse leukocytes. 1B1 detects β2-m associated CD1d.

Details

Host	Rat
Isotype	IgG2b, kappa
Reactivity	Mouse
Conjugate	Alexa Fluor 488
Laser	Blue Laser
Emit	519 nm
Excite	488 nm
Legal	Alexa Fluor® and Pacific Blue® are registered trademarks of and licensed under patents assigned to Molecular Probes, Inc. for research use only. This product is subject to an agreement between Molecular Probes, Inc. and eBioscience, and the manufacture, use, sale or import of this product may be subject to one or more U.S. patents, pending applications and corresponding foreign equivalents, owned by Molecular Probes, Inc. (a wholly owned subsidiary of Invitrogen Corp). The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product for life science research or as an ASR. The buyer cannot use this product for manufacturing or for any other screening (specifically including use in combination with microarrays or High Content Screening) or testing purpose, other than as an ASR. For information on purchasing a license to this product for purposes other than life science research or use as an ASR, contact Molecular Probes, Inc.
Reported Applications	Flow Cytometric Analysis

Documentation

For complete product information, please download the TDS or IFU document.

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
12-0011	Anti-Mouse CD1d PE	488 nm	575 nm	FC	RUO
16-0011	Anti-Mouse CD1d Functional Grade Purified			FC, FA	RUO
13-0011	Anti-Mouse CD1d Biotin			FC	RUO
11-0011	Anti-Mouse CD1d FITC (Discontinued)	488 nm	518 nm	FC	RUO
14-0011	Anti-Mouse CD1d Purified			FC, IHC, FA, IP	RUO

References

References: Brossay L, D.Jullien, S. Cardell, B.C. Sydora, N. Burdin, R.L Modlin, and M. Kronenberg. 1997. Mouse CD1 is mainly expressed on hemopoietic derived cells. J. Immunol. 159: 1216-1224.

Amano M., N. Baumgarth, M.D. Dick, L. Brossay, M. Kronenberg, L.A. Herzenberg, and S Strober 1998. CD1 expression defines subsets of follicular and marginal zone B cells in the spleen: beta2-microglobulin-dependent and independent forms. J. Immunol. 161:1710-1717.

Sydora B.C., L. Brossay, A. Hagenbaugh, M. Kronenberg, and H. Cheroutre. 1996. TAP-independent selection of CD8+ intestinal intraepithelial lymphocytes. J. Immunol. 156: 4209-4216.

Roark J.H., S.-H. Park, J. Jayawardena, U. Kavita, M. Shannon, and A. Bendelac. 1998. CD1.1 expression by mouse antigen-presenting cells and marginal zone B cells. J. Immunol. 160: 3121-3127.

Kawano, T. J. Cui, Y. Koezuka, I. Toura, Y. Kaneko, K. Motoki, H. Ueno, R. Nakagawa, H. Sato, E. Kondo, H. Koseki, and M. Taniguchi. 1997. CD1d-restricted and TCR-mediated activation of Valpha14 NKT cells by glycosylceramides. Science 278:1626-1629.

Brudin N., L. Brossay, Y. Koezuka, S. T. Smiley, M. J. Grusby, M. Gui, M. Taniguchi, K. Hayakawa, M. Kronenberg.1998. Selective Ability of Mouse CD1 to Present Glycolipids: alpha-Galactosylceramide Specifically Stimulates Valpha14+ NK T Lymphocytes. J. Immunol 161: 271-81.

Szalay G, Ladel CH, Blum C, Brossay L, Kronenberg M, Kaufmann SH Cutting edge: anti-CD1 monoclonal antibody treatment reverses the production patterns of TGF-beta 2 and Th1 cytokines and ameliorates listeriosis in mice. J Immunol. 1999 Jun 15;162(12):6955-8. (in vivo, PubMed)

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Antigens	Area of Biology	Cell Type	Formats
CD1d	Innate Immunity	Dendritic Cells	Alexa Fluor 488