Anti-Mouse CD19 PE-Cy5 (Discontinued. Alternative clone Cat. No. 15-0193)

Also known as: AW495831

Clone: MB19-1

RUO: For Research Use Only. Not for use in diagnostic procedures.

Attention: Alternative clone 1D3 is available. Refer to Cat. No. 15-0193

SKU# 15-0191

Cat. No.	Size
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Staining of C57Bl/6 splenocytes with Anti-Mouse CD3e (cat.12-0031) (left) or with 0.125 ug...View More

Description

Description: The MB19-1 monoclonal antibody reacts with mouse CD19, a 95 kDa transmembrane glycoprotein. CD19 is expressed by B cells during all stages of development excluding the terminally differentiated plasma cells. Follicular dendritic cells also express CD19. Together CD21, CD81, MHC class II, and CD19 form a multimolecular complex that associates with the BCR. Signaling through CD19 induces tyrosine phosphorylation, calcium flux and proliferation of B cells. Staining of B cells with MB19-1 and its conjugates is usually dimmer than the rat anti-mouse CD19 antibody, clone 6D5.

Details

Host	Mouse
Isotype	IgA, kappa
Reactivity	Mouse
Laser	Blue Laser, Green Laser, Yellow-Green Laser
Excite	488 - 561 nm
Legal	FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT # 5,268,486, 5,569,587 AND 5,627,027 AND FOREIGN EQUIVALENTS AND PENDING APPLICATIONS. THIS MATERIAL IS SUBJECT TO PROPRIETARY RIGHTS OF GE HEALTHCARE BIO-SCIENCES CORP. AND CARNEGIE MELLON UNIVERSITY AND MADE AND SOLD UNDER LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. THIS PRODUCT IS LICENSED FOR SALE ONLY FOR RESEARCH. IT IS NOT LICENSED FOR ANY OTHER USE. THERE IS NO IMPLIED LICENSE HEREUNDER FOR ANY COMMERCIAL USE. COMMERCIAL USE shall include: 1. sale, lease, license or other transfer of the material or any material derived or produced from it; 2. sale, lease, license or other grant of rights to use this Material or any material derived or produced from it; 3. use of this material to perform services for a fee for third parties. IF YOU REQUIRE A COMMERCIAL LICENSE TO USE THIS MATERIAL AND DO NOT HAVE ONE, RETURN THIS MATERIAL, UNOPENED TO EBIOSCIENCE, INC. 10255 SCIENCE CENTER DRIVE, SAN DIEGO, CALIFORNIA 92121 USA AND ANY MONEY PAID FOR THE MATERIAL WILL BE REFUNDED.
Reported Applications	Flow Cytometric Analysis

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
36-0191	Anti-Mouse CD19 Functional Grade Biotin			FC, FA, IP	RUO
11-0191	Anti-Mouse CD19 FITC	488 nm		FC	RUO
13-0191	Anti-Mouse CD19 Biotin			FC	RUO
16-0191	Anti-Mouse CD19 Functional Grade Purified			FC, FA, IP	RUO
14-0191	Anti-Mouse CD19 Purified			FC, FA, IP	RUO
17-0191	Anti-Mouse CD19 APC	633 - 647 nm	660 nm	FC	RUO
12-0191	Anti-Mouse CD19 PE	488 - 561 nm	575 nm	FC	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
12-0031	Anti-Mouse CD3e PE	488 - 561 nm	575 nm	FC	RUO

References

References: Engel, P., L. J. Zhou, et al. (1995).Immunity 3(1): 39-50.
Sato, S., N. Ono, et al. (1996). "CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity." J Immunol 157(10): 4371-8.
Sato, S., D. A. Steeber, et al. (1997). "CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19." J Immunol 158(10): 4662-9.
Tedder, T. F., M. Inaoki, et al. (1997). "The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity." Immunity 6(2): 107-18.

View More Products

Antigens	Area of Biology	Cell Type	Formats
CD19	Adaptive Immunity	B Cells	PE-Cyanine5