Anti-Mouse CD180 (RP105) Functional Grade Purified

Description: The RP/14 monoclonal antibody reacts with mouse CD180 (RP105). This 105 kDa type I transmembrane molecule is a member of the TLR family of proteins characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. RP105 physically associates with another molecule called MD-1 and is expressed on mature B cells, monocytes/macrophages and dendritic cells. Ligation of RP105 with RP/14 protects B cells from irradiation- or dexamethasone-induced apoptosis, and drives them to proliferate. B cells activated by RP105-ligation arrest their growth and undergo apoptosis when the antigen receptor is engaged. The RP105/MD-1 complex in concert with TLR4 mediates B cell recognition and signaling of LPS. Thus, RP105 is a signal transduction molecule and plays a role in regulation of B cell growth and death.

References:
Miyake, K., Y. Yamashita, et al. 1995. RP105, a novel B cell surface molecule implicated in B cell activation, is a member of the leucine-rich repeat protein family. J Immunol 154(7): 3333-40.
Miyake, K., R. Shimazu, et al. 1998. Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression. J Immunol 161(3): 1348-53.
Ogata, H., I. Su, et al. 2000. The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. J Exp Med 192(1): 23-9.