Anti-Mouse CD178 (Fas Ligand) APC

Description: The MFL3 monoclonal antibody reacts with mouse Fas (CD95) Ligand, a 40 kDa type II transmembrane glycoprotein. FasL is a member of the TNF family and is expressed by mouse activated T cells. The interaction of FasL with its receptor CD95 induces Fas-mediated killing. It has been reported that the human FasL antigen is cleaved from the surface by matrix metalloproteinases (MMPs), resulting in a 26 kDa soluble form. The degree of sensitivity for the mouse antigen to MMPs has not been reported.

References: Kayagaki, N., N. Yamaguchi, et al. 1997. Polymorphism of murine Fas ligand that affects the biological activity. Proc Natl Acad Sci U S A 94(8): 3914-9.

Nakajima, A., H. Hirai, et al. (2000). Treatment of lupus in NZB/W F1 mice with monoclonal antibody against fas ligand. J Autoimmun 14(2): 151-7.

Kayagaki, N., A. Kawasaki, et al. (1995). Metalloproteinase-mediated release of human Fas ligand. J Exp Med 182(6): 1777-83.