Anti-Rat CD161 PerCP-eFluor® 710

Description: This 10/78 monoclonal antibody recognizes rat CD161a, which is also known as NKR-P1A. A member of the NKR-P1 family of type II transmembrane C-type lectins, CD161a exists as a homodimer on all NK cells, some T cells, and monocytes. In the rat, this activating receptor is also detectable on B220+ single positive B cells. CD161a is involved in activating NK cell-mediated cytotoxicity via phosphoinositide turnover and intracellular calcium mobilization.

The 10/78 monoclonal antibody has been reported to recognize both NKR-P1A and NKR-P1B.

References: Hess S, Methe H, Kim JO, Edelman ER. NF-kappaB activity in endothelial cells is modulated by cell substratum interactions and influences chemokine-mediated adhesion of natural killer cells. Cell Transplant. 2009;18(3):261-73. (10/78, IHC-p)

Li J, Rabinovich BA, Hurren R, Shannon J, Miller RG. Expression cloning and function of the rat NK activating and inhibitory receptors NKR-P1A and -P1B. Int Immunol. 2003 Mar;15(3):411-6. (10/78, FC)

Ryan JC, Niemi EC, Goldfien RD, Hiserodt JC, Seaman WE. NKR-P1, an activating molecule on rat natural killer cells, stimulates phosphoinositide turnover and a rise in intracellular calcium. J Immunol. 1991 Nov 1;147(9):3244-50.

Scriba A, Schneider M, Grau V, van der Meide PH, Steiniger B. Rat monocytes up-regulate NKR-P1A and down-modulate CD4 and CD43 during activation in vivo: monocyte subpopulations in normal and IFN-gamma-treated rats. J Leukoc Biol. 1997 Dec;62(6):741-52.

Ryan JC, Niemi EC, Nakamura MC, Seaman WE. NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity. J Exp Med. 1995 May 1;181(5):1911-5.