Product References
TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.
Cell stem cell
Yamashita M,Passegué E
46-0161 was used in Flow cytometry/Cell sorting to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.
Thu Sep 05 00:00:00 EDT 2019
Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis.
Haematologica
Zhang Z,Huang Z,Ong B,Sahu C,Zeng H,Ruan HB
Published figure using CD16/CD32 monoclonal antibody (Product # 46-0161-82) in Flow Cytometry
Sun Sep 01 00:00:00 EDT 2019
miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling.
Nature communications
Lam J,van den Bosch M,Wegrzyn J,Parker J,Ibrahim R,Slowski K,Chang L,Martinez-Høyer S,Condorelli G,Boldin M,Deng Y,Umlandt P,Fuller M,Karsan A
Published figure using CD16/CD32 monoclonal antibody (Product # 46-0161-82) in Flow Cytometry
Wed Jun 20 00:00:00 EDT 2018
Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.
Nature
Hérault A,Binnewies M,Leong S,Calero-Nieto FJ,Zhang SY,Kang YA,Wang X,Pietras EM,Chu SH,Barry-Holson K,Armstrong S,Göttgens B,Passegué E
Published figure using CD16/CD32 monoclonal antibody (Product # 46-0161-82) in Flow Cytometry
Thu Apr 06 00:00:00 EDT 2017
Autophagy maintains the metabolism and function of young and old stem cells.
Nature
Ho TT,Warr MR,Adelman ER,Lansinger OM,Flach J,Verovskaya EV,Figueroa ME,Passegué E
46-0161 was used in Flow cytometry/Cell sorting to demonstrate an essential function for autophagy in removing activated mitochondria and controlling oxidative metabolism, thereby maintaining HSC stemness and regenerative potential.
Thu Mar 09 00:00:00 EST 2017
Differential cytokine contributions of perivascular haematopoietic stem cell niches.
Nature cell biology
Asada N,Kunisaki Y,Pierce H,Wang Z,Fernandez NF,Birbrair A,Ma'ayan A,Frenette PS
46-0161 was used in Flow cytometry/Cell sorting to demonstrate that the effects of cytokines regulating haematopoietic stem cell functions are dependent on the producing cell sources.
Wed Mar 01 00:00:00 EST 2017
Human umbilical cord blood-borne fibroblasts contain marrow niche precursors that form a bone/marrow organoid in vivo.
Development (Cambridge, England)
Pievani A,Sacchetti B,Corsi A,Rambaldi B,Donsante S,Scagliotti V,Vergani P,Remoli C,Biondi A,Robey PG,Riminucci M,Serafini M
46-0161 was used in Flow cytometry/Cell sorting to show that human umbilical cord blood-borne fibroblasts are able to recapitulate the conditions by which the bone marrow microenvironment is formed and establish complete hematopoietic stem cell niches.
Wed Mar 15 00:00:00 EDT 2017
Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy.
Nature communications
Liu Z,Ravindranathan R,Kalinski P,Guo ZS,Bartlett DL
Published figure using CD16/CD32 monoclonal antibody (Product # 46-0161-82) in Flow Cytometry
Mon Mar 27 00:00:00 EDT 2017
Single-cell analysis of mixed-lineage states leading to a binary cell fate choice.
Nature
Olsson A,Venkatasubramanian M,Chaudhri VK,Aronow BJ,Salomonis N,Singh H,Grimes HL
46-0161 was used in Flow cytometry/Cell sorting to propose that mixed-lineage states are obligatory during cell-fate specification, manifest differing frequencies because of their dynamic instability and are dictated by counteracting gene-regulatory networks.
Thu Sep 29 00:00:00 EDT 2016
DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia.
Cancer discovery
Meyer SE,Qin T,Muench DE,Masuda K,Venkatasubramanian M,Orr E,Suarez L,Gore SD,Delwel R,Paietta E,Tallman MS,Fernandez H,Melnick A,Le Beau MM,Kogan S,Salomonis N,Figueroa ME,Grimes HL
46-0161 was used in Flow cytometry/Cell sorting to study the mechanism by which Dnmt3a haploinsufficiency transforms Flt3-internal tandem duplication myeloproliferative disease within a clonogenic AML subpopulation.
Sun May 01 00:00:00 EDT 2016
Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.
Nature cell biology
Pietras EM,Mirantes-Barbeito C,Fong S,Loeffler D,Kovtonyuk LV,Zhang S,Lakshminarasimhan R,Chin CP,Techner JM,Will B,Nerlov C,Steidl U,Manz MG,Schroeder T,Passegué E
46-0161 was used in Flow cytometry/Cell sorting to identify a critical regulatory circuit that tailors HSC responses to acute needs, and is likely to underlie deregulated blood homeostasis in chronic inflammation conditions.
Wed Jun 01 00:00:00 EDT 2016
CD8+ T cells drive autoimmune hematopoietic stem cell dysfunction and bone marrow failure.
Journal of autoimmunity
Gravano DM,Al-Kuhlani M,Davini D,Sanders PD,Manilay JO,Hoyer KK
46-0161 was used in Flow cytometry/Cell sorting to investigate whether CD8+ T cells play a non-redundant role in driving bone marrow failure.
Thu Dec 01 00:00:00 EST 2016
Gliotoxin Suppresses Macrophage Immune Function by Subverting Phosphatidylinositol 3,4,5-Trisphosphate Homeostasis.
mBio
Schlam D,Canton J,Carreño M,Kopinski H,Freeman SA,Grinstein S,Fairn GD
Published figure using CD16/CD32 monoclonal antibody (Product # 46-0161-82) in Flow Cytometry
Tue Apr 05 00:00:00 EDT 2016
Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.
Journal for immunotherapy of cancer
Patel MA,Kim JE,Theodros D,Tam A,Velarde E,Kochel CM,Francica B,Nirschl TR,Ghasemzadeh A,Mathios D,Harris-Bookman S,Jackson CC,Jackson C,Ye X,Tran PT,Tyler B,Coric V,Selby M,Brem H,Drake CG,Pardoll DM,Lim M
Published figure using CD16/CD32 monoclonal antibody (Product # 46-0161-82) in Flow Cytometry
Wed May 18 00:00:00 EDT 2016
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.
Nature communications
Alvarez S,Díaz M,Flach J,Rodriguez-Acebes S,López-Contreras AJ,Martínez D,Cañamero M,Fernández-Capetillo O,Isern J,Passegué E,Méndez J
46-0161 was used in Flow cytometry/Cell sorting to determine that haematopoietic progenitors are particularly sensitive to replication stress.
Mon Oct 12 00:00:00 EDT 2015
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.
Nature
Flach J,Bakker ST,Mohrin M,Conroy PC,Pietras EM,Reynaud D,Alvarez S,Diolaiti ME,Ugarte F,Forsberg EC,Le Beau MM,Stohr BA,Méndez J,Morrison CG,Passegué E
46-0161 was used in Flow cytometry/Cell sorting to study functional decline in ageing haematopoietic stem cells due to replicative stress.
Thu Aug 14 00:00:00 EDT 2014
FOXO3A directs a protective autophagy program in haematopoietic stem cells.
Nature
Warr MR,Binnewies M,Flach J,Reynaud D,Garg T,Malhotra R,Debnath J,Passegué E
46-0161 was used in Flow cytometry/Cell sorting to show how FOXO3A directs a protective autophagy program in haematopoietic stem cells.
Thu Feb 21 00:00:00 EST 2013
Morphine decreases bacterial phagocytosis by inhibiting actin polymerization through cAMP-, Rac-1-, and p38 MAPK-dependent mechanisms.
The American journal of pathology
Ninković J,Roy S
Published figure using CD16/CD32 monoclonal antibody (Product # 46-0161-82) in Flow Cytometry
Thu Mar 01 00:00:00 EST 2012
Morphine decreases bacterial phagocytosis by inhibiting actin polymerization through cAMP-, Rac-1-, and p38 MAPK-dependent mechanisms.
The American journal of pathology
Ninković J,Roy S
Published figure using CD16/CD32 monoclonal antibody (Product # 46-0161-82) in Flow Cytometry
Thu Mar 01 00:00:00 EST 2012
In vivo inhibition of c-MYC in myeloid cells impairs tumor-associated macrophage maturation and pro-tumoral activities.
PloS one
Pello OM,Chèvre R,Laoui D,De Juan A,Lolo F,Andrés-Manzano MJ,Serrano M,Van Ginderachter JA,Andrés V
Published figure using CD16/CD32 monoclonal antibody (Product # 46-0161-82) in Flow Cytometry
Mon Feb 25 00:00:00 EST 2013