Anti-Mouse CD153 Functional Grade Purified

Description: The RM153 monoclonal antibody reacts with mouse CD153 (CD30 ligand). This 40 kDa cell surface receptor, a type II transmembrane protein, is a member of the TNF superfamily. Interaction of CD30 with CD153 plays an important role in T cell activation/costimulation. Expression of CD153 on T cells does not appear to require costimulation through CD28 and is upregulated via TCR engagement and peaks 24-48 hours after activation. Signaling through CD153 is important in costimulation of pre-activated T cells.

References: Shimozato O, Takeda K, Yagita H, Okumura K .Expression of CD30 ligand (CD153) on murine activated T cells. Biochem Biophys Res Commun. 1999 Mar 24;256(3):519-26.