Anti-Mouse CD147 Purified

Description: The RL73 monoclonal antibody reacts with mouse CD147, also known as Basigin. CD147 is expressed by a majority of thymocytes, activated peripheral T cells, erythrocytes and erythroblasts. It has been reported that CD147 expression correlates with cycling of immature thymocytes even in the absence of TCR beta selection and that ligation of this molecule on immature fetal thymocytes inhibits their further development into mature T cells.

References: MacDonald HR, Lees RK, Bron C. 1985. Cell surface glycoproteins involved in the stimulation of interleukin 1-dependent interleukin 2 production by a subline of EL4 thymoma cells. I. Functional characterization by monoclonal antibodies. J Immunol. 135(6):3944-50.

Renno T, Wilson A, Dunkel C, Coste I, Maisnier-Patin K, Benoit de Coignac A, Aubry JP, Lees RK, Bonnefoy JY, MacDonald HR, Gauchat JF. 2002. A role for CD147 in thymic development. J Immunol.168(10):4946-50.

Coste I, Gauchat JF, Wilson A, Izui S, Jeannin P, Delneste Y, MacDonald HR, Bonnefoy JY, Renno T. 2001. Unavailability of CD147 leads to selective erythrocyte trapping in the spleen. Blood. 97(12):3984-8.