Anti-Mouse CD140b (PDGF Receptor b) Purified

Description: The APB5 monoclonal antibody reacts with the mouse CD140b molecule, the β chain of the platelet derived growth factor receptor (PDGF receptor). PDGFRb is a receptor tyrosine kinase that forms dimers on the surface upon ligand binding and phosphorylates substrates. Dimers of PDGFR consist of either homodimers of α/α, β/β, or heterodimers of α/β and serve as a substrate for its kinase activity. CD140b is expressed by embryonic tissues and mesenchymal-derived cells of the adult mouse tissues. The PDGFR β chain is reported to play a significant role in formation of fibrous atherosclerotic lesions.

References: Sano, H., T. Sudo, et al. 2001. Functional blockade of platelet-derived growth factor receptor-beta but not of receptor-alpha prevents vascular smooth muscle cell accumulation in fibrous cap lesions in apolipoprotein E-deficient mice. Circulation 103(24): 2955-60.

Takakura, N., H. Yoshida, et al. 1997. PDGFR alpha expression during mouse embryogenesis: immunolocalization analyzed by whole-mount immunohistostaining using the monoclonal anti-mouse PDGFR alpha antibody APA5. J Histochem Cytochem 45(6): 883-93.

Sano H, Yokode M, Takakura N, Takemura G, Doi T, Kataoka H, Sudo T, Nishikawa S, Fujiwara H, Nishikawa SI,and Kita S. (2001) Study on PDGF Receptor ß Pathway in Glomerular Formation in Neonate Mice Annals of the New York Academy of Sciences 947:303-305 (FA)