Anti-Mouse CD137 Ligand (4-1BB Ligand) Functional Grade Purified

Description: The TKS-1 monoclonal antibody reacts with mouse 4-1BB Ligand (4-1BBL), a type II transmembrane protein and a member of the tumor necrosis factor superfamily. 4-1BBL is expressed by activated antigen presenting cells including B cells and macrophages. Interaction of 4-1BBL with 4-1BB (CDw137) is reported to deliver a costimulatory signal important in the T-APC interaction.

References: Zheng G, Wang B, Chen A. The 4-1BB costimulation augments the proliferation of CD4+CD25+ regulatory T cells. J Immunol. 2004 Aug 15;173(4):2428-34.(TKS-1, FC, PubMed)

Futagawa T, Akiba H, Kodama T, Takeda K, Hosoda Y, Yagita H, Okumura K.Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells. Int Immunol. 2002 Mar;14(3):275-86.

Akiba H, Miyahira Y, Atsuta M, Takeda K, Nohara C, Futagawa T, Matsuda H, Aoki T, Yagita H, Okumura K. Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. J Exp Med. 2000 Jan 17;191(2):375-80.