Anti-Mouse CD126 Functional Grade Purified

Description: The monoclonal antibody D7715A7 recognizes mouse CD126, the IL-6 receptor α chain, a member of the Ig superfamily. CD126 can heterodimerize with CD130 (gp130) to form the high affinity IL-6 receptor. Once IL-6 is bound, signaling from the CD130 subunit is initiated and the receptor complex is internalized. The IL-6 receptor is also reported to exist as a soluble version, which bound to IL-6 acts in trans to signal. Expression is found on T lymphocytes in the periphery and during development in the thymus is restricted to SP populations, unlike gp130 which is expressed in all thymocytes. Additional expression has been shown on activated B lymphocytes, macrophages, granulocytes and CD34+ hematopoietic progenitor cells. The monoclonal antibody D7715A7 binding can be blocked addition of ligand (IL-6).

References: Betz UA, Müller W. Regulated expression of gp130 and IL-6 receptor alpha chain in T cell maturation and activation.Int Immunol. 1998 Aug;10(8):1175-84.

Hurchla MA, Sedy JR, Murphy KM.Unexpected role of B and T lymphocyte attenuator in sustaining cell survival during chronic allostimulation.J Immunol. 2007 May 15;178(10):6073-82. (D17715A7, FC, PubMed)

Koizumi N, Yamaguchi T, Kawabata K, Sakurai F, Sasaki T, Watanabe Y, Hayakawa T, Mizuguchi H. Fiber-modified adenovirus vectors decrease liver toxicity through reduced IL-6 production.J Immunol. 2007 Feb 1;178(3):1767-73. (D17715A7, FA, PubMed)

Vink A, Coulie P, Warnier G, Renauld JC, Stevens M, Donckers D, Van Snick J. Mouse plasmacytoma growth in vivo: enhancement by interleukin 6 (IL-6) and inhibition by antibodies directed against IL-6 or its receptor.J Exp Med. 1990 Sep 1;172(3):997-1000. (D17715A7, FA, PubMed)