Anti-Mouse CD122 PE

Description: The TM-b1 monoclonal antibody reacts with mouse CD122, the 90-110 kDa interleukin-2 receptor beta chain (IL-2R beta). CD122 is expressed by NK cells and some T cells in the periphery, and is upregulated by activation. CD122 associates with CD25 and CD132 (common gamma chain) to form the high affinity IL-2 receptor. High affinity binding of IL-2 to the IL-2 receptor is inhibited by the TM-b1 antibody.

References: French JD, Roark CL, Born WK, O'brien RL. Gamma delta T cell homeostasis is established in competition with alpha beta T cells and NK cells. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14741-6. (TM-b1, FA blocking, PubMed)

Takeuchi Y, Tanaka T, Hamamura K, Sugimoto T, Miyasaka M, Yagita H, Okumura K. 1992. Expression and role of interleukin-2 receptor beta chain on CD4-CD8- T cell receptor alpha beta+ cells. Eur J Immunol. 22(11):2929-35.

Tanaka T, Takeuchi Y, Shiohara T, Kitamura F, Nagasaka Y, Hamamura K, Yagita H, Miyasaka M. 1992. In utero treatment with monoclonal antibody to IL-2 receptor beta-chain completely abrogates development of Thy-1+ dendritic epidermal cells. Int Immunol. 4(4):487-91.