Anti-Mouse CD11b PE-Cyanine7

Also known as: Integrin alpha M, ITGAM, Mac-1 alpha (Mac1A), Complement Receptor 3 alpha (CR3A)

Clone: M1/70

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 25-0112

Cat. No.	Size
25-0112-81	50 ug
25-0112-82	100 ug
Please inquire about custom configurations or bulk packaging.

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Description

Description: The M1/70 monoclonal antibody reacts with mouse CD11b, the 165-170 kDa integrin α_M. CD11b non-covalently associates with CD18 to form α_Mβ₂ integrin (Mac-1) and binds to CD54 (ICAM-1), C3bi, and fibrinogen. Mac-1 is expressed by macrophages, NK cells, granulocytes, activated lymphocytes and mouse B-1 cells in the peritoneal cavity. M1/70 is also cross-reactive to human CD11b, and can be used for the detection of this antigen on human peripheral blood monocytes, granulocytes, and a subset of NK cells. Through interactions with its ligands, CD11b participates in adhesive cell interactions.

Details

Host	Rat
Isotype	IgG2b, kappa
Reactivity	Mouse
Conjugate	PE-Cyanine7
Laser	Blue Laser, Green Laser, Yellow-Green Laser
Emit	775 nm
Excite	488 - 561 nm
Legal	FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT # 5,268,486, 5,569,587 AND 5,627,027 AND FOREIGN EQUIVALENTS AND PENDING APPLICATIONS. THIS MATERIAL IS SUBJECT TO PROPRIETARY RIGHTS OF GE HEALTHCARE BIO-SCIENCES CORP. AND CARNEGIE MELLON UNIVERSITY AND MADE AND SOLD UNDER LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. THIS PRODUCT IS LICENSED FOR SALE ONLY FOR RESEARCH. IT IS NOT LICENSED FOR ANY OTHER USE. THERE IS NO IMPLIED LICENSE HEREUNDER FOR ANY COMMERCIAL USE. COMMERCIAL USE shall include: 1. sale, lease, license or other transfer of the material or any material derived or produced from it; 2. sale, lease, license or other grant of rights to use this Material or any material derived or produced from it; 3. use of this material to perform services for a fee for third parties. IF YOU REQUIRE A COMMERCIAL LICENSE TO USE THIS MATERIAL AND DO NOT HAVE ONE, RETURN THIS MATERIAL, UNOPENED TO EBIOSCIENCE, INC. 10255 SCIENCE CENTER DRIVE, SAN DIEGO, CALIFORNIA 92121 USA AND ANY MONEY PAID FOR THE MATERIAL WILL BE REFUNDED.
Reported Applications	Flow Cytometric Analysis

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
IH93-0112	Anti-Mouse CD11b eFluor® 605NC (for IHC/ICC)	350 - 590 nm	605 nm	ICC, IHC	RUO
17-0112	Anti-Mouse CD11b APC	633 - 647 nm	660 nm	FC	RUO
11-0112	Anti-Mouse CD11b FITC	488 nm	518 nm	FC	RUO
93-0112	Anti-Mouse CD11b eFluor® 605NC	350 - 590 nm	605 nm	FC	RUO
19-0112	Anti-Mouse CD11b Cy5	633 - 647 nm	670 nm	FC	RUO
12-0112	Anti-Mouse CD11b PE	488 - 561 nm	575 nm	FC	RUO
56-0112	Anti-Mouse CD11b Alexa Fluor® 700	633 nm	723 nm	FC	RUO
53-0112	Anti-Mouse CD11b Alexa Fluor® 488	488 nm	519 nm	FC	RUO
50-0112	Anti-Mouse CD11b eFluor® 660 (Alexa Fluor® 647 Replacement)	633 nm	668 nm	FC	RUO
16-0112	Anti-Mouse CD11b Functional Grade Purified			FC, FA	RUO
15-0112	Anti-Mouse CD11b PE-Cyanine5	488 - 561 nm		FC	RUO
47-0112	Anti-Mouse CD11b APC-eFluor® 780	633 - 647 nm	780 nm	FC	RUO
IH95-0112	Anti-Mouse CD11b eFluor® 650NC (for IHC/ICC)	350 - 635 nm	650 nm	ICC, IHC	RUO
36-0112	Anti-Mouse CD11b Functional Grade Biotin			FC, IHC, FA, IP	RUO
14-0112	Anti-Mouse CD11b Purified			FC, IHC, FA, IP	RUO
45-0112	Anti-Mouse CD11b PerCP-Cyanine5.5	488 nm		FC	RUO
48-0112	Anti-Mouse CD11b eFluor® 450	405 nm		FC	RUO
13-0112	Anti-Mouse CD11b Biotin			FC	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
25-4031	Rat IgG2b K Isotype Control PE-Cyanine7	488 - 561 nm	775 nm	FC	RUO

References

References: Zhang Y, McCormick LL, et al. 2002. Murine sclerodermatous graft-versus-host disease, a model for human scleroderma: cutaneous cytokines, chemokines, and immune cell activation. J Immunol. 168(6):3088-98. (IHC frozen, PubMed)

Dembic Z, Schenck K, and Bogen B. 2000. Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4+ T cells. Proc Natl Acad Sci U S A. 97(6):2697-702. (IHC frozen, PubMed)

Whiteland JL, Nicholls SM, et al. 1995. Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies. J Histochem Cytochem. 43(3):313-20. (IHC paraffin, PubMed)

Sanchez-Madrid, F., P. Simon, et al. 1983. Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1. J Exp Med 158(2): 586-602.

Ault KA and Springer TA. 1981. Cross-reaction of a rat-anti-mouse phagocyte-specific monoclonal antibody (anti-Mac-1) with human monocytes and natural killer cells. J Immunol. 126(1):359-64. (cross-reactivity to human, PubMed)

Springer, T., G. Galfre, et al. 1978. Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. Eur J Immunol 8(8): 539-51.

Springer, T., G. Galfre, et al. 1979. Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur J Immunol 9(4): 301-6.

View More Products

Antigens	Area of Biology	Cell Type	Formats
CD11b	Adhesion & Migration Innate Immunity Angiogenesis	Macrophage & Monocyte Cells NK & NKT Cells	PE-Cyanine7