Anti-Mouse CD119 (IFN gamma Receptor 1) Biotin

Description: The monoclonal antibody 2E2 recognizes mouse CD119 also known as IFN gamma receptor1. CD119 heterodimerizes with IFN gamma receptor 2 (AF-1) forming the Class II cytokine receptor. The ligand IFN gamma binds IFN gamma receptor 1 subunit but signal transduction transpires via the IFN gamma receptor 2 subunit. The receptor is involved in host defense and expression is broad including B cells, NK cells, macrophages and dendritic cells as well as other non-hematopoietic cell types.

References: Feng C, Keisler DH, Fritsche KL. Dietary omega-3 polyunsaturated fatty acids reduce IFN-gamma receptor expression in mice. J Interferon Cytokine Res. 1999 Jan;19(1):41-8.

Bach EA, Aguet M, Schreiber RD. The IFN gamma receptor: a paradigm for cytokine receptor signaling.Annu Rev Immunol. 1997;15:563-91. Review.