Anti-Mouse CD117 (c-Kit) PE-Cy5.5 (To Be Discontinued; See Replacement Formats: PerCP-eFluor® 710 or PerCP-Cy5.5)

Also known as: cKit, Steel Factor Receptor, Mast/stem cell growth factor receptor, SCFR, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit

Clone: 2B8

RUO: For Research Use Only. Not for use in diagnostic procedures.

Attention: To Be Discontinued. See Replacement Formats PerCP-eFluor? 710 or PerCP-Cy5.5

SKU# 35-1171

Cat. No.	Size
35-1171-81	50 ug
35-1171-82	100 ug

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Description

Description: The 2B8 monoclonal antibody reacts with mouse CD117, also known as c-Kit receptor, Steel factor receptor and stem cell factor receptor. A member of the tyrosine kinase receptor family, this 145 kDa molecule is expressed by a majority of hematopoietic progenitor cells characterized in the mouse bone marrow as a small subset of cells positive for Sca-1 and Thy1 (Thy1^lo) and negative for lineage markers. The interaction of the mouse c-kit receptor and steel factor promotes the proliferation and differentiation of hematopoietic progenitor cells. CD117 is also expressed by mast cells and plays a role in signaling and activation of these cells.

Details

Host	Rat
Isotype	IgG2b, kappa
Reactivity	Mouse
Emit	690 nm
Excite	488 nm
Legal	FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT # 5,268,486, 5,569,587 AND 5,627,027 AND FOREIGN EQUIVALENTS AND PENDING APPLICATIONS. THIS MATERIAL IS SUBJECT TO PROPRIETARY RIGHTS OF GE HEALTHCARE BIO-SCIENCES CORP. AND CARNEGIE MELLON UNIVERSITY AND MADE AND SOLD UNDER LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. THIS PRODUCT IS LICENSED FOR SALE ONLY FOR RESEARCH. IT IS NOT LICENSED FOR ANY OTHER USE. THERE IS NO IMPLIED LICENSE HEREUNDER FOR ANY COMMERCIAL USE. COMMERCIAL USE shall include: 1. sale, lease, license or other transfer of the material or any material derived or produced from it; 2. sale, lease, license or other grant of rights to use this Material or any material derived or produced from it; 3. use of this material to perform services for a fee for third parties. IF YOU REQUIRE A COMMERCIAL LICENSE TO USE THIS MATERIAL AND DO NOT HAVE ONE, RETURN THIS MATERIAL, UNOPENED TO EBIOSCIENCE, INC. 10255 SCIENCE CENTER DRIVE, SAN DIEGO, CALIFORNIA 92121 USA AND ANY MONEY PAID FOR THE MATERIAL WILL BE REFUNDED.
Reported Applications	Flow Cytometric Analysis

Documentation

For complete product information, please download the TDS or IFU document.

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
19-1171	Anti-Mouse CD117 (c-Kit) Cy5	633 nm	670 nm	FC	RUO
12-1171	Anti-Mouse CD117 (c-Kit) PE	488 nm	575 nm	FC	RUO
13-1171	Anti-Mouse CD117 (c-Kit) Biotin			FC	RUO
11-1171	Anti-Mouse CD117 (c-Kit) FITC	488 nm	518 nm	FC	RUO
17-1171	Anti-Mouse CD117 (c-Kit) APC	633 nm	660 nm	FC	RUO
46-1171	Anti-Mouse CD117 (c-Kit) PerCP-eFluor® 710 (PE-Cy5.5 replacement)	488 nm	710 nm	FC	RUO
25-1171	Anti-Mouse CD117 (c-Kit) PE-Cy7	488 nm	760 nm	FC	RUO
14-1171	Anti-Mouse CD117 (c-Kit) Purified			FC, IP	RUO
47-1171	Anti-Mouse CD117 (c-Kit) APC-eFluor® 780	633 nm	780 nm	FC	RUO
15-1171	Anti-Mouse CD117 (c-Kit) PE-Cy5	488 nm	670 nm	FC	RUO

References

References: Ikuta K, Weissman IL. 1992. Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc Natl Acad Sci USA. 89(4): 1502-6.

View More Products

Antigens	Area of Biology	Cell Type
CD117 (c-kit)	Stem Cell Biology Cell Signaling Angiogenesis	Hematopoietic Stem Cells