Anti-Mouse CD102 (ICAM-2) Alexa Fluor® 488

Also known as: ICAM2, Ly-60

Clone: 3C4 (mIC2/4)

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 53-1021

Cat. No.	Size
53-1021-80	25 ug
53-1021-82	100 ug
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Staining of C57BL/6 splenocytes with 0.125 ug of Rat IgG2a kappa Isotype Control Alexa Fluor® 488...View More

Description

Description: The monoclonal antibody 3C4 (mIC2/4) recognizes mouse CD102, also known as intercellular adhesion molecule-2 (ICAM-2). CD102, a member of the Immunoglobulin superfamily of receptors with 2 extracellular Ig domains, binds LFA (CD11a/CD18) and Mac-1 (CD11b/CD18), thereby mediating cellular interactions to lymphocytes. CD102 plays a role in NK cytotoxicity and migration, and lymphocyte recirculation. Expression of CD102 is found on most lymphocytes, monocytes and platelets.

The 3C4 (mIC2/4) antibody blocks interaction of lymphocytes with antigen presenting cells.

Details

Host	Rat
Isotype	IgG2a, kappa
Reactivity	Mouse
Conjugate	Alexa Fluor 488
Laser	Blue Laser
Emit	519 nm
Excite	488 nm
Legal	Alexa Fluor® and Pacific Blue® are registered trademarks of and licensed under patents assigned to Molecular Probes, Inc. for research use only. This product is subject to an agreement between Molecular Probes, Inc. and eBioscience, and the manufacture, use, sale or import of this product may be subject to one or more U.S. patents, pending applications and corresponding foreign equivalents, owned by Molecular Probes, Inc. (a wholly owned subsidiary of Invitrogen Corp). The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product for life science research or as an ASR. The buyer cannot use this product for manufacturing or for any other screening (specifically including use in combination with microarrays or High Content Screening) or testing purpose, other than as an ASR. For information on purchasing a license to this product for purposes other than life science research or use as an ASR, contact Molecular Probes, Inc.
Reported Applications	Flow Cytometric Analysis, Immunohistochemical Staining of Frozen Tissue Sections

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
14-1021	Anti-Mouse CD102 (ICAM-2) Purified			FC, IHC, IP	RUO
48-1021	Anti-Mouse CD102 (ICAM-2) eFluor® 450	405 nm	450 nm	FC	RUO
13-1021	Anti-Mouse CD102 (ICAM-2) Biotin			FC	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
53-4321	Rat IgG2a K Isotype Control Alexa Fluor® 488	488 nm	519 nm	FC, ICC, IHC	RUO

References

References: Gerwin N, Gonzalo JA, Lloyd C, Coyle AJ, Reiss Y, Banu N, Wang B, Xu H, Avraham H, Engelhardt B, Springer TA, Gutierrez-Ramos JC. Prolonged eosinophil accumulation in allergic lung interstitium of ICAM-2 deficient mice results in extended hyperresponsiveness. Immunity. 1999 Jan;10(1):9-19. (3C4, FC, IHC/IF, PubMed)

Xu H, Bickford JK, Luther E, Carpenito C, Takei F, Springer TA. Characterization of murine intercellular adhesion molecule-2. J Immunol. 1996 Jun 15;156(12):4909-14. (3C4, mAb characterization, IP, FA, PubMed)

View More Products

Antigens	Area of Biology	Cell Type	Formats
CD102 (ICAM-2)	Adaptive Immunity Adhesion & Migration Angiogenesis	B Cells Dendritic Cells Macrophage & Monocyte Cells T Cells	Alexa Fluor 488