Anti-Mouse CD101 PE

Description: The monoclonal antibody moushi101 recognizes mouse CD101, also known as IGSF2 and V7 (7 IgV domains). CD101 is a transmembrane glycoprotein containing 7 Ig-like IgV domains and a short cytoplasmic tail with several phosphorylation sites. Cross-linking CD101 can antagonize TCR/CD3-mediated lymphocyte activation. CD101 is expressed on monocytes, granulocytes, dendritic cells, Langerhans cells and activated T cells. In addition, CD101 is found on a subset of CD25+Foxp3+ T regulatory cells that showed higher suppressive properties in vitro and in vivo.

References: Fernandez I, Zeiser R, Karsunky H, Kambham N, Beilhack A, Soderstrom K, Negrin RS, Engleman E. CD101 surface expression discriminates potency among murine FoxP3+ regulatory T cells. J Immunol. 2007 Sep 1;179(5):2808-14.

Soares LR, Tsavaler L, Rivas A, Engleman EG.V7 (CD101) ligation inhibits TCR/CD3-induced IL-2 production by blocking Ca2+ flux and nuclear factor of activated T cell nuclear translocation. J Immunol. 1998 Jul 1;161(1):209-17.

Bagot M, Martinel I, Charue D, Weill F, Boulland ML, Wechsler J, Freeman GJ, Bensussan A, Boumsell L.CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation.Tissue Antigens. 1997 Nov;50(5):439-48.