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Staining of C57Bl/6 splenocytes with 0.125 ug of Rat IgG2a kappa Isotype Control Functional Grade...View More
Description: The BMA12 monoclonal antibody reacts with mouse CD100, also known as Sema4D. Sema4D/CD100 is a 150kDa transmembrane protein expressed constitutively on T cells and is involved in the activation of B cells through its interaction with CD72. Interaction of these two proteins diminishes the negative signaling normally effected by CD72. CD100 is already expressed strongly on resting T cells and somewhat weakly on B cells, but activation upregulates expression on both cell types. Antigen expression has been reported in Spleen, thymus and lymph nodes.
References: Wang X, Kumanogoh A, Watanabe C, Shi W, Yoshida K, Kikutani H. 2001. Functional soluble CD100/Sema4D released from activated lymphocytes: possible role in normal and pathologic immune responses. Blood. 97(11):3498-504.
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