Mouse CCL19-Fc (MIP-3 beta) Fusion Recombinant Protein

Description: The purified mouse CCL19-Fc is a fusion protein of the mouse CCL19 chemokine with the human Fcγ fragment. The purified mouse CCL19-Fc can be used for the detection of mouse CCR7 expression when used with a fluorochrome-conjugated anti-human Fc antibody. CCR7 is a chemokine receptor for the chemokines CCL19 (CKβ11, ELC, MIP3β, Scya19, Exodus-3) and CCL21 (CKβ9, SLC, MIP2β, Scya21, Exodus-2). In recent years, the role of chemokines in directing the migration of lymphocytes has been well-characterized. One of the most important mediators of homeostatic trafficking of naïve T cells to secondary lymphoid organs (SLO) is the chemokine receptor CCR7. Binding of its ligands, CCL19 and CCL21, mediates the transendothelial migration of T cells across high endothelial venules into SLO. It has also been demonstrated that CCR7 plays a role in the localization of dendritic cells and B cells during an immune response.

In addition to its significant role in the chemotaxis of lymphocytes, human CCR7 has also been recognized as a marker for a distinct subset of memory T cells, the central memory (T_CM) population. These cells are characterized by the expression of CCR7 and CD62L and reside within peripheral lymphoid organs.

CCR7 also plays a role in thymocyte development and its deficiency leads to disturbed thymic architecture, aberrant T cell development, and limited thymocyte expansion.

References: Anis MM, Fulton SA, Reba SM, Liu Y, Harding CV, Boom WH. Modulation of pulmonary dendritic cell function during mycobacterial infection.Infect Immun. 2008 Feb;76(2):671-7. (CCL19-Fc, PubMed)

Hargreaves DC, Hyman PL, Lu TT, Ngo VN, Bidgol A, Suzuki G, Zou YR, Littman DR, Cyster JG. A coordinated change in chemokine responsiveness guides plasma cell movements.J Exp Med. 2001 Jul 2;194(1):45-56.

Misslitz A, Pabst O, Hintzen G, Ohl L, Kremmer E, Petrie HT, Forster R. Thymic T cell development and progenitor localization depend on CCR7.J Exp Med. 2004 Aug 16;200(4):481-91.

Junt T, Scandella E, Forster R, Krebs P, Krautwald S, Lipp M, Hengartner H, Ludewig B. Impact of CCR7 on priming and distribution of antiviral effector and memory CTL.J Immunol. 2004 Dec 1;173(11):6684-93.