Anti-Mouse CCL11 (Eotaxin) Purified (To be Discontinued)

Description: The Eotaxin polyclonal antibody reacts with recombinant and natural mouse Eotaxin (CCL11). This was generated using E. coli-expressed amino acids 1-74 of mature mouse CCL11 as an immunogen. CCL11 is a 74-amino acid eosinophil-chemotactic CC chemokine originally found in bronchoalveolar lavage fluid from allergic inflammatory subjects. It is involved in regulating the recruitment and activation of inflammatory leukocytes, particularly eosinophils. It may play a fundamental role in the development of allergic responses. Cross-reactivity to CCL11 of other species has not been determined.

References: Jose PJ, et al. 1994. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. J Exp Med. 179: 881-887. Kitaura M, et al. 1996. Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. J Biol Chem. 271:7725-7730. Garcia-Zepeda EA, et al. 1996. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nat Med. 2:449-456. Ganzalo, JS, et al. 1996. Mouse eotaxin expression parallels eosinophil accumulation during lung allergic inflammation but it is not restricted to a Th2-type response. Immunity. 4:1-14.