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Anti-Mouse c-Rel Purified

Clone: 1RELAH5

RUO: For Research Use Only. Not for use in diagnostic procedures.

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SKU# 14-6111

Cat. No. Size
14-6111-80 25 ug
14-6111-82 100 ug

Data for Anti-Mouse c-Rel Purified.

Immunoblotting of reduced mouse splenocyte cell lysate with 5 ug/mL Anti-Mouse c-Rel Purified...View More

  • Data for Anti-Mouse c-Rel Purified.
Description

Description: The 1RELAH5 monoclonal antibody reacts with mouse c-Rel. c-Rel is a 65 kDa hematopoietic lineage-restricted member of the NF-kB family of transcription factors. In the thymus, c-Rel is upregulated in regulatory T cells (Treg) when compared to other CD4+ thymocytes. c-Rel is believed to play a critical role in thymic Treg (nTreg) development, but is not necessary for TGF beta-mediated T reg (iTreg) differentiation. C-Rel is also involved in proliferation and survival in mature T cells.

Details
Host Rat
Isotype IgG2a, kappa
Reactivity Mouse
Conjugate Purified
Reported Applications Western Blotting
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
12-6111 Anti-Mouse c-Rel PE 488 - 561 nm 578 nm FC RUO
50-6111 Anti-Mouse c-Rel eFluor® 660 633 - 647 nm 668 nm FC RUO
References

References: Hsu FC, Shapiro MJ, Dash B, Chen CC, Constans MM, Chung JY, Romero Arocha SR, Belmonte PJ, Chen MW, McWilliams DC, Shapiro VS. An essential role for the transcription factor Runx1 in T cell maturation. Sci Rep. 2016 Mar 29;6:23533. (1RELAH5, FC, PubMed)

Loizou L, Andersen KG, Betz AG. Foxp3 Interacts with c-Rel to Mediate NF-kB Repression. PLoS One. 2011 Apr 7;6(4):e18670.

Isomura I, Palmer S, Grumont RJ, Bunting K, Hoyne G, Wilkinson N, Banerjee A, Proietto A, Gugasyan R, Wu L, McNally A, Steptoe RJ, Thomas R, Shannon MF, Gerondakis S. c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells. J Exp Med. 2009 Dec 21;206(13):3001-14.

Ruan Q, Kameswaran V, Tone Y, Li L, Liou HC, Greene MI, Tone M, Chen YH. Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome. Immunity. 2009 Dec 18;31(6):932-40.

Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol. 2002 Oct;2(10):725-34.

Carrasco D, Weih F, Bravo R. Developmental expression of the mouse c-rel proto-oncogene in hematopoietic organs. Development. 1994 Oct;120(10):2991-3004.


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