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Anti-Mouse c-Rel PE

Also known as: Rel

Clone: 1RELAH5

RUO: For Research Use Only. Not for use in diagnostic procedures.

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SKU# 12-6111

Cat. No. Size
12-6111-80 25 ug
12-6111-82 100 ug

Data for Anti-Mouse c-Rel PE.

Mouse thymocytes were stained with Anti-Mouse CD4, Anti-Mouse CD8 and Anti-Mouse CD25, then fixed...View More

  • Data for Anti-Mouse c-Rel PE.
Description

Description: The 1RELAH5 monoclonal antibody reacts with mouse c-Rel. c-Rel is a 65 kDa hematopoietic lineage-restricted member of the NF-kB family of transcription factors. In the thymus, c-Rel is upregulated in regulatory T cells (Treg) when compared to other CD4+ thymocytes. c-Rel is believed to play a critical role in thymic Treg (nTreg) development, but is not necessary for TGF beta-mediated T reg (iTreg) differentiation. C-Rel is also involved in proliferation and survival in mature T cells.

Details
Host Rat
Isotype IgG2a, kappa
Reactivity Mouse
Conjugate PE
Laser Blue Laser, Green Laser, Yellow-Green Laser
Emit 578 nm
Excite 488 - 561 nm
Reported Applications Flow Cytometric Analysis, Intracellular Staining Followed by Flow Cytometric Analysis
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
50-6111 Anti-Mouse c-Rel eFluor® 660 633 - 647 nm 668 nm FC RUO
14-6111 Anti-Mouse c-Rel Purified WB RUO
Related Products
Cat. No. Name Excite Emit Application Reg.
00-5521 Foxp3 / Transcription Factor Fixation/Permeabilization Concentrate and Diluent FC GPR
11-0042 Anti-Mouse CD4 FITC 488 nm 520 nm FC RUO
12-4321 Rat IgG2a K Isotype Control PE 488 - 561 nm 578 nm FC RUO
48-0081 Anti-Mouse CD8a eFluor® 450 405 nm 445 nm FC RUO
00-5523 Foxp3 / Transcription Factor Staining Buffer Set FC GPR
11-5773 Anti-Mouse/Rat Foxp3 FITC 488 nm 520 nm FC, IHC RUO
45-0251 Anti-Mouse CD25 PerCP-Cyanine5.5 488 nm 695 nm FC RUO
56-5773 Anti-Mouse/Rat Foxp3 Alexa Fluor® 700 633 - 647 nm 723 nm FC RUO
References

References: Hsu FC, Shapiro MJ, Dash B, Chen CC, Constans MM, Chung JY, Romero Arocha SR, Belmonte PJ, Chen MW, McWilliams DC, Shapiro VS. An essential role for the transcription factor Runx1 in T cell maturation. Sci Rep. 2016 Mar 29;6:23533. (1RELAH5, FC, PubMed)

Loizou L, Andersen KG, Betz AG. Foxp3 Interacts with c-Rel to Mediate NF-kB Repression. PLoS One. 2011 Apr 7;6(4):e18670.

Isomura I, Palmer S, Grumont RJ, Bunting K, Hoyne G, Wilkinson N, Banerjee A, Proietto A, Gugasyan R, Wu L, McNally A, Steptoe RJ, Thomas R, Shannon MF, Gerondakis S. c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells. J Exp Med. 2009 Dec 21;206(13):3001-14.

Ruan Q, Kameswaran V, Tone Y, Li L, Liou HC, Greene MI, Tone M, Chen YH. Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome. Immunity. 2009 Dec 18;31(6):932-40.

Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol. 2002 Oct;2(10):725-34.

Carrasco D, Weih F, Bravo R. Developmental expression of the mouse c-rel proto-oncogene in hematopoietic organs. Development. 1994 Oct;120(10):2991-3004.


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