Anti-Mouse BP-1 Purified

Description: The 6C3 monoclonal antibody reacts with mouse BP-1, also known as Ly-51 and 6C3 antigen. BP-1 is a 140 kDa type II transmembrane protein that is present on the surface as a disulfide-linked homodimer. This molecule is an enzyme with aminopeptidase A (APA) activity and is expressed by bone marrow stromal cells, thymic cortical epithelial cells and at early stages of mouse B cell development, on pre-B cells. The low level of BP-1 expression on pre-B cells can be upregulated in the presence of IL-7.

References: Pillemer E., C. Whitlok, I. L. Weissman. 1984. Transformatino-associate proteins in murine B-cell lymphomas that are distinct from Abelosn virus gene products. Proc. Natl. Acad. Sci. 81:4434-4438
Morse III, H. C., G. F. Tidmarsh, K. L. Holmes, T. F. Frederickson, J. N. Hartley, J. H. Pierce, W. Y. Langdon, M. O. Dailey, and I. L. Weissman. 1987. Expression of the 6C3 antigen on murine hematopoietic neoplasms. Association with expression of abl, ras, fes, src, erbB, and Cas NS-1 oncogenes but not with myc. J. Exp. Med. 165:920-925
Wu, Q., G. F. Tidmarsh, P. A. Welch, J. H. Pierce, I. L. Weissman, M. D. Cooper. 1989. The early B linage antigen BP-1 and the transformation-associated antigen 6C3 are on the same molecule. J. Immunol. 143:3303-3308