Monkey sICAM-1 Platinum ELISA

Description: The monkey sICAM-1 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of monkey sICAM-1. The monkey sICAM-1 ELISA is for research use only. Not for diagnostic or therapeutic procedures.

Intercellular Adhesion Molecule-1 (ICAM-1) is a member of the immunoglobulin supergene family and functions as a ligand for the Lymphocyte Function-Associated Antigen-1 (LFA-1), an alpha-beta-complex that is a member of the leukocyte integrin family of cell-cell and cell-matrix receptors. This family consists of the leukocyte adhesion glycoproteins LFA-1 which mediates lymphocyte adhesion, Mac-1 which mediates granulocyte adhesion and p150,95.

ICAM-1 is a single-chain glycoprotein with a polypeptide core that can be expressed on non-hematopoietic cells of many lineages such as vascular endothelial cells, thymic epithelial cells, other epithelial cells and fibroblasts and on hematopoietic cells such as tissue macrophages, mitogen-stimulated T-lymphoblasts, germinal center B-cells and dendritic cells in tonsils, lymph nodes and Peyer's patches. ICAM-1 is inducible on fibroblasts and endothelial cells by inflammatory mediators such as IL-1, TNF and IFN-gamma within few hours and is correlated to the infiltration of lymphocytes into inflammatory lesions. ICAM-1 seems to be the initial marker of inflammatory reactions and is expressed prior to, and to a greater extent than is HLA-DR.

The role of ICAM-1 as a disease marker has been demonstrated for a number of different indications and pathological situations.

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Dustin,M.L.; Rothlein,R.; Bhan,A.K.; Dinarello,C.A.; Springer,T.A.. Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J.Immunol. 1986;137:245-254. (Link)

Lampeter,E.R.; Kishimoto,T.K.; Rothlein,R.; Mainolfi,E.A.; Bertrams,J.; Kolb,H.; Martin,S.. Elevated levels of circulating adhesion molecules in IDDM patients and in subjects at risk for IDDM. Diabetes 1992;41:1668-1671. (Link)

Vejlsgaard,G.L.; Ralfkiaer,E.; Avnstorp,C.; Czajkowski,M.; Marlin,S.D.; Rothlein,R.. Kinetics and characterization of intercellular adhesion molecule-1 (ICAM-1) expression on keratinocytes in various inflammatory skin lesions and malignant cutaneous lymphomas. J.Am.Acad.Dermatol. 1989;20:782-790. (Link)

Lal,R.B.; Mainolfi,E.; Rothlein,R.. Elevated levels of cICAM-1 in patients with human T-cell leukemia virus type I associated myelopathy and adult T-cell leukemia. Blood 1992;80:2434-2435. (Link)

Salafia,C.M.; DeVore,G.R.; Mainolfi,E.; Kelly,J.; Pezzullo,J.C.; Rothlein,R.. Circulating intercellular adhesion molecule-1 in amniotic fluid, maternal serum alpha-fetoprotein levels, and intrauterine growth retardation. Am.J.Obstet.Gynecol. 1993;169:830-834. (Link)

Most,J.; Zangerle,R.; Herold,M.; Fuchs,D.; Wachter,H.; Fritsch,P.; Dierich,M.P.. Elevated concentrations of circulating intercellular adhesion molecule 1 (ICAM-1) in HIV-1 infection. J.Acquir.Immune Defic.Syndr. 1993;6:221-226. (Link)

Lisby,S.; Ralfkiaer,E.; Rothlein,R.; Vejlsgaard,G.L.. Intercellular adhesion molecule-I (ICAM-I) expression correlated to inflammation. Br.J.Dermatol. 1989;120:479-484. (Link)

Rothlein,R.; Dustin,M.L.; Marlin,S.D.; Springer,T.A.. A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J.Immunol. 1986;137:1270-1274. (Link)

Harning,R.; Mainolfi,E.; Bystryn,J.C.; Henn,M.; Merluzzi,V.J.; Rothlein,R.. Serum levels of circulating intercellular adhesion molecule 1 in human malignant melanoma. Cancer Res. 1991;51:5003-5005. (Link)

Adams,D.H.; Hubscher,S.G.; Shaw,J.; Rothlein,R.; Neuberger,J.M.. Intercellular adhesion molecule 1 on liver allografts during rejection. Lancet 1989;2:1122-1125. (Link)

Potocnik,A.J.; Kinne,R.; Menninger,H.; Zacher,J.; Emmrich,F.; Kroczek,R.A.. Expression of activation antigens on T cells in rheumatoid arthritis patients. Scand.J.Immunol. 1990;31:213-224. (Link)

Becker,J.C.; Dummer,R.; Schwinn,A.; Hartmann,A.A.; Burg,G.. Circulating intercellular adhesion molecule-1 in melanoma patients: induction by interleukin-2 therapy. J.Immunother.(1991.) 1992;12:147-150. (Link)

Marlin,S.D.; Springer,T.A.. Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1). Cell 1987;51:813-819. (Link)

Adams,D.H.; Mainolfi,E.; Elias,E.; Neuberger,J.M.; Rothlein,R.. Detection of circulating intercellular adhesion molecule-1 after liver transplantation--evidence of local release within the liver during graft rejection. Transplantation 1993;55:83-87. (Link)

Rothlein,R.; Czajkowski,M.; O'Neill,M.M.; Marlin,S.D.; Mainolfi,E.; Merluzzi,V.J.. Induction of intercellular adhesion molecule 1 on primary and continuous cell lines by pro-inflammatory cytokines. Regulation by pharmacologic agents and neutralizing antibodies. J.Immunol. 1988;141:1665-1669. (Link)

Wegner,C.D.; Gundel,R.H.; Reilly,P.; Haynes,N.; Letts,L.G.; Rothlein,R.. Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma. Science 1990;247:456-459. (Link)