Monkey IL-6 Instant ELISA

Description: The monkey IL-6 Instant ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of monkey IL-6. The monkey IL-6 Instant ELISA is for research use only. Not for diagnostic or therapeutic procedures.

Interleukin-6 (IL-6) is a multi-functional cytokine that regulates immune responses, acute phase reactions and hematopoiesis and may play a central role in host defense mechanisms.
IL-6 is usually not produced constitutively by normal cells, but its expression is readily induced by a variety of cytokines, lipopolysaccharide or viral infections. IL-6 is a pleiotropic cytokine produced by a variety of cells. It acts on a wide range of tissues, exerting growth-induction, growth-inhibition, and differentiation respectively, depending on the nature of the target cells.

IL-6 is involved in:
- the induction of B-cell differentiation,
- the induction of acute phase proteins in liver cells,
- growth promotion of myeloma/plasmacytoma/hybridoma cells,
- induction of IL-2 and IL-2 receptor expression,
- proliferation and differentiation of T cells,
- inhibition of cell growth of certain myeloid leukemic cell lines and induction of their differentiation to macrophages,
- enhancement of IL-3-induced multipotential colony cell formation in hematopoietic stem cells and induction of maturation of megakaryocytes as a thrombopoietic factor,
- induction of mesangial cell growth, induction of neural differentiation of PC 12 cells and
- induction of keratinocyte growth

The abnormal production of IL-6 was first suggested to be related to polyclonal B-cell activation with autoantibody production in patients with cardiac myxoma. Since then, IL-6 has been suggested to be involved in the pathogenesis of a variety of diseases. Measurement of IL-6 levels in serum and other body fluids thus provides more detailed insights into various pathological situations.

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Hirano,T.; Yasukawa,K.; Harada,H.; Taga,T.; Watanabe,Y.; Matsuda,T.; Kashiwamura,S.; Nakajima,K.; Koyama,K.; Iwamatsu,A.; .. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 1986;324:73-76. (Link)

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May,L.T.; Ghrayeb,J.; Santhanam,U.; Tatter,S.B.; Sthoeger,Z.; Helfgott,D.C.; Chiorazzi,N.; Grieninger,G.; Sehgal,P.B.. Synthesis and secretion of multiple forms of beta 2-interferon/B-cell differentiation factor 2/hepatocyte-stimulating factor by human fibroblasts and monocytes. J.Biol.Chem. 1988;263:7760-7766. (Link)

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Horii,Y.; Iwano,M.; Hirata,E.; Shiiki,M.; Fujii,Y.; Dohi,K.; Ishikawa,H.. Role of interleukin-6 in the progression of mesangial proliferative glomerulonephritis. Kidney Int.Suppl 1993;39:S71-S75. (Link)

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Hirano,T.; Taga,T.; Yasukawa,K.; Nakajima,K.; Nakano,N.; Takatsuki,F.; Shimizu,M.; Murashima,A.; Tsunasawa,S.; Sakiyama,F.; .. Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production. Proc.Natl.Acad.Sci.U.S.A 1987;84:228-231. (Link)