STAT1 InstantOne ELISA Kit Performance
STAT1 is known to mediate IFN (interferon) signaling. STAT1 accomplishes this by either forming a heterodimer with STAT2 as a result of Type I IFN (IFNa and IFNβ) binding that activates the JAK kinase or through homodimerization in response to IFN. activation. In the canonical STAT activation, JAK kinases are activated downstream of cytokine signaling and phosphorylate various STAT family proteins. This phosphorylation allows for the dimerization of the STATs through their SH2 domains. This dimer then binds other proteins and translocates into the nucleus where it binds to DNA, most notably, to the interferon stimulated response element (ISRE) that drives the cell into an antiviral state.