IL-17 Family of Cytokines

IL-17 Cytokine Family

Interleukin-17 (IL-17) is a family of 6 closely related cytokines that includes IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (IL-25), and IL-17F that function in immune response as either homodimers or heterodimers with other family members. Cell type and tissue expression patterns differ greatly between the family members, but there is significant overlap in receptor binding patterns between IL-17 family members.

Overall, IL-17 functions in host defense against extracellular bacterial and fungal infections and contributes to the pathogenesis of various autoimmune inflammatory diseases.  The unusual structure of both the IL-17 cytokines and their receptors has presented a new paradigm in cytokine biology:

  • IL-17A, the prototypic family member, is the most widely studied member of the family and is most similar to IL-17F, the second most studied family member.  IL-17A appears to be more involved in autoimmunity than IL-17F, while the in vivo role of IL-17AF is still largely unknown.
  • IL-17A, IL-17E, and IL-17F are important pro-inflammatory cytokines.
  • Much less is known about IL-17B, IL-17C, and IL-17D and their functions remain poorly understood. 

With the recent availability of new research reagents such as monoclonal antibodies, ELISAs, multiplex assays, and recombinant proteins for the IL-17AF specific heterodimer, advances in  the knowledge of its roles and functions should increase.

IL-17 Family of Cytokines

Select your IL-17 family antigen of interest below to learn more and see data examples.

References for IL-17 Family of Cytokines

The following references are used in the content for all pages in the IL-17 family of cytokines.

  • Bulek, K. et al. The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation. Nature Immunology 12, 844-852 (2011).
  • Hirota, K. et al. Fate mapping of IL-17-producing T cells in inflammatory responses. Nature Immunology 12, 255-263 (2011).
  • May, M.J.  IL17R signaling: New Players get in on the Act1. Nature Immunology 12, 813-815 (2011).
  • Cua, D.J. and Tato, C.M. Innate IL-17-producing cells: the sentinels of the immune system. Nature Reviews Immunology 10, 479-489 (2010).
  • Qian, Y., Kang, Z., Liu, C., and Li, X. IL-17 signaling in host defense and inflammatory diseases. Cellular& Molecular Immunology 7, 328-333 (2010).
  • Nature Drug Discovery 9, 908 (2010)
  • Gaffen, S.L.  Structure and Signalling in the IL-17 Receptor Family. Nature Reviews Immunology 9, 556-567 (2009).