Description: This FlowCytomix Simplex Kit is designed for the measurement of Human FLT-4 in an immunoassay analyzed on a flow cytometer. Together with the FlowCytomix Human Basic Kit (cat. BMS8420FF), this kit can be used to detect FLT-4 alone or can be multiplexed with other Simplex Kits to measure a variety of analytes.
This kit contains bead population A11.
VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis. Several studies have shown positive correlations between VEGF-C, VEGF-D and VEGFR-3 expression and vascular invasion, lymphatic vessel and lymph node involvement.
Heterozygous missense point mutations leading to receptor kinase inactivation have been found in VEGFR-3 of patients with Milroy disease, a rare autosomal dominant lymph oedema. Metastatic tumour spread through the blood or lymphatic vessels in human cancer, often associated with regional lymph-node metastasis, represents the most important prognostic factor for carcinoma patients.