This site will redirect to thermofisher.com on April 7. Get details >


Anti-Human V beta 9 TCR PE

Also known as: Vbeta 9, Vb9

Clone: AMKB1-2

RUO: For Research Use Only. Not for use in diagnostic procedures.

These products are now available on thermofisher.com. Find out more >

SKU# 12-4899

Cat. No. Size
12-4899-42 100 tests

Data for Anti-Human V beta 9 TCR PE.

Staining of normal human peripheral blood cells with Anti-Human CD3 FITC (cat. 11-0038) and Mouse...View More

  • Data for Anti-Human V beta 9 TCR PE.
Description

Description: This AMKB1-2 monoclonal antibody recognizes the human T cell receptor (TCR) Vβ9 allele. Composed of an α and β chain, TCR specificity is typically determined by Vα, Jα, Vβ, Dβ, and Jβ gene rearrangement. Vβ expression in humans has been examined in studies on the effects of superantigens, inflammation, autoimmune disease, and HIV infection. More recently, assessment of TCR Vβ expression has been used to phenotype T cell clonality in CD3+/TCRαβ+ large granular lymphocyte leukemias. A member of the Ig superfamily, this receptor is expressed on a subset of peripheral blood T cells.

Details
Host Mouse
Isotype IgG1, kappa
Reactivity Human
Conjugate PE
Laser Blue Laser, Green Laser, Yellow-Green Laser
Emit 578 nm
Excite 488 - 561 nm
Reported Applications Flow Cytometric Analysis
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
17-4899 Anti-Human V beta 9 TCR APC 633 - 647 nm 660 nm FC RUO
Related Products
Cat. No. Name Excite Emit Application Reg.
11-0038 Anti-Human CD3 FITC 488 nm 520 nm FC RUO
11-0037 Anti-Human CD3 FITC 488 nm 520 nm FC RUO
12-4714 Mouse IgG1 K Isotype Control PE 488 - 561 nm 578 nm FC RUO
References

References: Lima M, Almeida J, Santos AH, dos Anjos Teixeira M, Alguero MC, Queirós ML, Balanzategui A, Justiça B, Gonzalez M, San Miguel JF, Orfao A. Immunophenotypic analysis of the TCR-Vbeta repertoire in 98 persistent expansions of CD3(+)/TCR-alphabeta(+) large granular lymphocytes: utility in assessing clonality and insights into the pathogenesis of the disease. Am J Pathol. 2001 Nov;159(5):1861-8.

Dong T, Stewart-Jones G, Chen N, Easterbrook P, Xu X, Papagno L, Appay V, Weekes M, Conlon C, Spina C, Little S, Screaton G, van der Merwe A, Richman DD, McMichael AJ, Jones EY, Rowland-Jones SL. HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptor. J Exp Med. 2004 Dec 20;200(12):1547-57.

Stuart PM, Munn RK, DeMoll E, Woodward JG. Characterization of human T-cell responses to Yersinia enterocolitica superantigen. Hum Immunol. 1995 Aug;43(4):269-75. (AMKB1-2, FC, Pubmed)

Choi YW, Kotzin B, Lafferty J, White J, Pigeon M, Kubo R, Kappler J, Marrack P. A method for production of antibodies to human T-cell receptor beta-chain variable regions. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8357-61.


View More Products

AntigensArea of BiologyCell TypeFormats