Anti-Human V beta 5.1 TCR APC

Description: This LC4 monoclonal antibody recognizes the human T cell receptor (TCR) Vβ5.1 allele. Composed of an α and β chain, TCR specificity is typically determined by Vaα, Jα, Vβ, Dβ, and Jβ gene rearrangement. Vβ expression in humans has been examined in studies on the effects of superantigens, inflammation, autoimmune disease, and HIV infection. More recently, assessment of TCR Vβ expression has been used to phenotype T cell clonality in CD3+/TCRαβ+ large granular lymphocyte leukemias. A member of the Ig superfamily, this receptor is expressed on a subset of peripheral blood T cells.

This monoclonal antibody has been reported to induce apoptosis and calcium flux.

References: Dong T, Stewart-Jones G, Chen N, Easterbrook P, Xu X, Papagno L, Appay V, Weekes M, Conlon C, Spina C, Little S, Screaton G, van der Merwe A, Richman DD, McMichael AJ, Jones EY, Rowland-Jones SL. HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptor. J Exp Med. 2004 Dec 20;200(12):1547-57.

Liima M, Almeida J, Santos AH, dos Anjos Teixeira M, Alguero MC, Queirós ML, Balanzategui A, Justiça B, Gonzalez M, San Miguel JF, Orfão A. Immunophenotypic analysis of the TCR-Vbeta repertoire in 98 persistent expansions of CD3(+)/TCR-alphabeta(+) large granular lymphocytes: utility in assessing clonality and insights into the pathogenesis of the disease. Am J Pathol. 2001 Nov;159(5):1861-8.

Choi YW, Kotzin B, Lafferty J, White J, Pigeon M, Kubo R, Kappler J, Marrack P. A method for production of antibodies to human T-cell receptor beta-chain variable regions. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8357-61.

Takahashi S, Maecker HT, Levy R. DNA fragmentation and cell death mediated by T cell antigen receptor/CD3 complex on a leukemia T cell line. Eur J Immunol. 1989 Oct;19(10):1911-9. (LC4, FA,Pubmed)

Maecker HT, Levy R. Prevalence of antigen receptor variants in human T cell lines and tumors. J Immunol. 1989 Feb 15;142(4):1395-404. (LC4, FC,Pubmed)