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Anti-Human Trop2 (EGP-1) Purified

Clone: MR54

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 14-6024

Cat. No. Size
14-6024-80 25 ug
14-6024-82 100 ug
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Data for Anti-Human Trop2 (EGP-1) Purified.

Immunohistochemistry on formalin-fixed paraffin embedded human infiltrating ductal carcinoma, using...View More

  • Data for Anti-Human Trop2 (EGP-1) Purified.
Description

Description: This MR54 monoclonal antibody reacts with human Trop-2, which is also known as Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) and EGP-1. This type I transmembrane glycoprotein is expressed on trophoblast (syncytiotrophoblast and cytotrophoblast), epithelial, and most human carcinoma cells. Trop-2 plays a role in calcium-mediated signaling. Trop-2 has also been reported as an oncogene, with expression being correlated with tumorigenesis, metastasis, and anchorage-independent growth.

Details
Host Mouse
Isotype IgG2a, kappa
Reactivity Human
Conjugate Purified
Reported Applications Flow Cytometric Analysis, ELISA, Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections, Immunocytochemistry, Immunoprecipitation, Western Blotting
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
53-6024 Anti-Human Trop2 (EGP-1) Alexa Fluor® 488 488 nm 519 nm FC, ICC, IHC RUO
12-6024 Anti-Human Trop2 (EGP-1) PE 488 - 561 nm FC RUO
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References

References: Cubas R, Zhang S, Li M, Chen C, Yao Q. Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. Mol Cancer. 2010 Sep 21;9:253.

Ripani E, Sacchetti A, Corda D, Alberti S. Human Trop-2 is a tumor-associated calcium signal transducer. Int J Cancer. 1998 May 29;76(5):671-6.

Stein R, Basu A, Goldenberg DM, Llyod KO, and Mattes MJ. Charaterization of cluster 13: The epithelial/carcinoma antigen recognized by MAb RS7. Int. J. Cancer Suppl. 1994. 8:98-102. (MR54, FC, WB, ELISA)

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