Anti-Human Trop2 (EGP-1) Alexa Fluor® 488

Clone: MR54

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 53-6024

Cat. No.	Size
53-6024-80	25 ug
53-6024-82	100 ug
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Immunocytochemistry on fixed MCF-7 cells using 10 ug/mL Mouse IgG1 Isotype Control Alexa Fluor® 488...View More

Description

Description: This MR54 monoclonal antibody reacts with human Trop-2, which is also known as Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) and EGP-1. This type I transmembrane glycoprotein is expressed on trophoblast (syncytiotrophoblast and cytotrophoblast), epithelial, and most human carcinoma cells. Trop-2 plays a role in calcium-mediated signaling. Trop-2 has also been reported as an oncogene, with expression being correlated with tumorigenesis, metastasis, and anchorage-independent growth.

Details

Host	Mouse
Isotype	IgG2a, kappa
Reactivity	Human
Conjugate	Alexa Fluor 488
Laser	Blue Laser
Emit	519 nm
Excite	488 nm
Legal	Alexa Fluor® is a registered trademark of and licensed under patents assigned to Molecular Probes, Inc. for research use only. This product is subject to an agreement between Molecular Probes, Inc. and eBioscience, and the manufacture, use, sale or import of this product may be subject to one or more U.S. patents, pending applications and corresponding foreign equivalents, owned by Molecular Probes, Inc. (a wholly owned subsidiary of Invitrogen Corp). The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product for life science research or as an ASR. The buyer cannot use this product for manufacturing or for any other screening (specifically including use in combination with microarrays or High Content Screening) or testing purpose, other than as an ASR. For information on purchasing a license to this product for purposes other than life science research or use as an ASR, contact Molecular Probes, Inc.
Reported Applications	Flow Cytometric Analysis, Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections, Immunocytochemistry

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
14-6024	Anti-Human Trop2 (EGP-1) Purified			FC, ELISA, ICC, IHC, IP, WB	RUO
12-6024	Anti-Human Trop2 (EGP-1) PE	488 - 561 nm		FC	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
00-4953	IHC /ICC Blocking Buffer - Low Protein			ICC, IHC	GPR
00-4954	20X TBS Wash Buffer for IHC/ICC			ICC, IHC	GPR
00-4958	Fluoromount-G™			ICC, IHC	GPR
53-4724	Mouse IgG2a K Isotype Control Alexa Fluor® 488	488 nm	519 nm	FC, ICC, IHC	RUO
00-4955	IHC Antigen Retrieval Solution – Low pH (10X)			IHC	GPR
00-4956	IHC Antigen Retrieval Solution – High pH (10X)			IHC	GPR

References

References: Cubas R, Zhang S, Li M, Chen C, Yao Q. Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. Mol Cancer. 2010 Sep 21;9:253.

Ripani E, Sacchetti A, Corda D, Alberti S. Human Trop-2 is a tumor-associated calcium signal transducer. Int J Cancer. 1998 May 29;76(5):671-6.

Stein R, Basu A, Goldenberg DM, Llyod KO, and Mattes MJ. Charaterization of cluster 13: The epithelial/carcinoma antigen recognized by MAb RS7. Int. J. Cancer Suppl. 1994. 8:98-102. (MR54, FC, WB, ELISA)

View More Products

Antigens	Area of Biology	Formats
Trop-2	Adhesion & Migration Cell Cycle & Proliferation Cell Signaling	Alexa Fluor 488