Anti-Human TNF alpha PE-Cyanine7

Also known as: Tumor Necrosis Factor alpha

Clone: MAb11

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 25-7349

Cat. No.	Size
25-7349-41	25 tests
25-7349-82	100 ug
Please inquire about custom configurations or bulk packaging.

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Description

Description: The MAb11 antibody reacts with human tumor necrosis factor-alpha (TNF alpha), a 17 kDa cytokine produced by monocytes, macrophages, neutrophils, NK cells and CD4+ T cells. TN alpha has cytolytic activity against a range of tumor cells and is important in immune regulation. TNF alpha forms dimers and trimers and also exists as a 26 kDa membrane bound form. The MAb11 antibody is a neutralizing antibody.

Details

Host	Mouse
Isotype	IgG1, kappa
Reactivity	Human
Conjugate	PE-Cyanine7
Laser	Blue Laser, Green Laser, Yellow-Green Laser
Emit	775 nm
Excite	488 - 561 nm
Legal	FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT # 5,268,486, 5,569,587 AND 5,627,027 AND FOREIGN EQUIVALENTS AND PENDING APPLICATIONS. THIS MATERIAL IS SUBJECT TO PROPRIETARY RIGHTS OF GE HEALTHCARE BIO-SCIENCES CORP. AND CARNEGIE MELLON UNIVERSITY AND MADE AND SOLD UNDER LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. THIS PRODUCT IS LICENSED FOR SALE ONLY FOR RESEARCH. IT IS NOT LICENSED FOR ANY OTHER USE. THERE IS NO IMPLIED LICENSE HEREUNDER FOR ANY COMMERCIAL USE. COMMERCIAL USE shall include: 1. sale, lease, license or other transfer of the material or any material derived or produced from it; 2. sale, lease, license or other grant of rights to use this Material or any material derived or produced from it; 3. use of this material to perform services for a fee for third parties. IF YOU REQUIRE A COMMERCIAL LICENSE TO USE THIS MATERIAL AND DO NOT HAVE ONE, RETURN THIS MATERIAL, UNOPENED TO EBIOSCIENCE, INC. 10255 SCIENCE CENTER DRIVE, SAN DIEGO, CALIFORNIA 92121 USA AND ANY MONEY PAID FOR THE MATERIAL WILL BE REFUNDED.
Reported Applications	Intracellular Staining Followed by Flow Cytometric Analysis

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
56-7349	Anti-Human TNF alpha Alexa Fluor® 700	633 - 647 nm	723 nm	FC	RUO
14-7349	Anti-Human TNF alpha Purified			FC	RUO
13-7349	Anti-Human TNF alpha Biotin			ELISA	RUO
53-7349	Anti-Human TNF alpha Alexa Fluor® 488	488 nm	519 nm	FC	RUO
12-7349	Anti-Human TNF alpha PE	488 - 561 nm	575 nm	FC	RUO
17-7349	Anti-Human TNF alpha APC	633 - 647 nm	660 nm	FC	RUO
48-7349	Anti-Human TNF alpha eFluor® 450	405 nm	450 nm	FC	RUO
45-7349	Anti-Human TNF alpha PerCP-Cyanine5.5	488 nm		FC	RUO
11-7349	Anti-Human TNF alpha FITC	488 nm	518 nm	FC	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
00-8222	IC Fixation Buffer			FC	GPR
00-8333	Permeabilization Buffer (10X)			FC	GPR
11-0049	Anti-Human CD4 FITC	488 nm	518 nm	FC	RUO
14-8329	Human TNF alpha Recombinant Protein			ELISA, FA	RUO
25-4714	Mouse IgG1 K Isotype Control PE-Cyanine7	488 - 561 nm	775 nm	FC	RUO
88-8823	Intracellular Fixation & Permeabilization Buffer (plus Brefeldin A) (previously named IC Fixation & Permeabilization Buffer)			FC	GPR

References

References: Andersen H, Rossio JL, Coalter V, Poore B, Martin MP, Carrington M, Lifson JD. Characterization of rhesus macaque natural killer activity against a rhesus-derived target cell line at the single-cell level. Cell Immunol. 2004 Sep-Oct;231(1-2):85-95 (Mab11, crossreactivity to rhesus)

Danis VA, Franic GM, Rathjen DA, Brooks PM. Effects of granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-2, interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha) and IL-6 on the production of immunoreactive IL-1 and TNF-alpha by human monocytes. Clin Exp Immunol. 1991 Jul;85(1):143-50.

Rathjen DA, Cowan K, Furphy LJ, Aston R. Antigenic structure of human tumour necrosis factor: recognition of distinct regions of TNF alpha by different tumour cell receptors. Mol Immunol. 1991 Jan-Feb;28(1-2):79-86.

View More Products

Antigens	Area of Biology	Cell Type	Formats
TNF alpha	Apoptosis Cytokines, Chemokines, Growth Factors Innate Immunity	Macrophage & Monocyte Cells NK & NKT Cells T Cells Th1 Cells	PE-Cyanine7