Human TIMP-1 Platinum ELISA

Also known as: Tissue inhibitor of metalloproteinases, EPA

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# BMS2018*

Cat. No.	Size
BMS2018	96 tests
BMS2018TEN	10 x 96 tests
Please inquire about custom configurations or bulk packaging.

To enable ordering, please select your country. Cookies will need to be enabled to continue on our website. View our Privacy Policy.

Click on image to view more information.

Description

Description: The human TIMP-1 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human tissue inhibitior of metallo-proteinase-1 (TIMP-1). The human TIMP-1 ELISA is for research use only. Not for diagnostic or therapeutic procedures.

The tissue inhibitions of metalloproteinases (TIMPs) are naturally occurring proteins that specifically inhibit matrix metalloproteinases, thus maintaining balance between matrix destruction and formation. An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors.

TIMP-1 has been shown to inhibit tumor-induced angiogenesis. An imbalance of MMP/TIMP regulation has been implicated in several inflammatory diseases of the nervous system. In the pathogenesis of vascular diseases TIMP-1 seems to be down regulated.

Details

Reactivity	Human
Sample Volume	20 uL (1:100 prediluted)
Suitable Sample Types	cell culture supernatant, serum, plasma (EDTA, heparin)
Sensitivity	10.0 pg/mL
Standard Curve Range	39 - 2,500 pg/mL
Expected Value	172 ng/ml
Components	Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to human TIMP-1 Biotin-Conjugate anti-human TIMP-1 polyclonal antibody Streptavidin-HRP Human TIMP-1 Standard lyophilized, 5 ng/ml upon reconstitution Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA) Wash Buffer Concentrate 20x (PBS with 1% Tween 20) Substrate Solution (tetramethyl-benzidine) Stop Solution (1M Phosphoric acid) Blue-Dye Green-Dye Red-Dye Adhesive Films
Reported Applications	ELISA

Documentation

TDS Link	Download TDS

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
BMS2022*	Human MMP-13 Platinum ELISA			ELISA	RUO
BMS82022FF*	Human MMP-13 FlowCytomix Simplex			Multiplex	RUO
BMS2014/2*	Human MMP-3 Platinum ELISA	488 - 561 nm	575 nm	ELISA	RUO

References

References: Wojtowicz-Praga,S.M.; Dickson,R.B.; Hawkins,M.J.. Matrix metalloproteinase inhibitors. Invest New Drugs 1997;15:61-75. (Link)

Hornebeck,W.. Down-regulation of tissue inhibitor of matrix metalloprotease-1 (TIMP-1) in aged human skin contributes to matrix degradation and impaired cell growth and survival. Pathol.Biol.(Paris) 2003;51:569-573. (Link)

Yan,L.; Moses,M.A.. A case of tumor betrayal: biphasic effects of TIMP-1 on Burkitt's lymphoma. Am.J.Pathol. 2001;158:1185-1190. (Link)

Shin,W.S.; Szuba,A.; Rockson,S.G.. The role of chemokines in human cardiovascular pathology: enhanced biological insights. Atherosclerosis 2002;160:91-102. (Link)

Nagase,H.; Meng,Q.; Malinovskii,V.; Huang,W.; Chung,L.; Bode,W.; Maskos,K.; Brew,K.. Engineering of selective TIMPs. Ann.N.Y.Acad.Sci. 1999;878:1-11. (Link)

Thorgeirsson,U.P.; Lindsay,C.K.; Cottam,D.W.; Gomez,D.E.. Tumor invasion, proteolysis, and angiogenesis. J.Neurooncol. 1994;18:89-103. (Link)

Gardner,J.; Ghorpade,A.. Tissue inhibitor of metalloproteinase (TIMP)-1: the TIMPed balance of matrix metalloproteinases in the central nervous system. J.Neurosci.Res. 2003;74:801-806. (Link)

Arthur,M.J.; Iredale,J.P.. Hepatic lipocytes, TIMP-1 and liver fibrosis. J.R.Coll.Physicians Lond 1994;28:200-208. (Link)

Nagase,H.; Brew,K.. Designing TIMP (tissue inhibitor of metalloproteinases) variants that are selective metalloproteinase inhibitors. Biochem.Soc.Symp. 2003;201-212. (Link)

View More Products

Antigens	Area of Biology	Formats
TIMP-1	Adhesion & Migration Angiogenesis	Biotin