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Anti-Human CD366 (TIM3) Super Bright 436

Also known as: HAVCR2, T cell immunoglobulin and mucin domain-containing protein 3

Clone: F38-2E2

RUO: For Research Use Only. Not for use in diagnostic procedures.

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SKU# 62-3109

Cat. No. Size
62-3109-41 25 tests
62-3109-42 100 tests

Data for Anti-Human CD366 (TIM3) Super Bright 436.

Staining of unstimulated (left) or Anti-Human CD3 and CD28 Functional Grade Purified (cat. 16-0037...View More

  • Data for Anti-Human CD366 (TIM3) Super Bright 436.
Description

Description: This F38-2E2 monoclonal antibody reacts with human CD366, also known as T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) or HAVCR2. This cell surface receptor is expressed on activated CD4+ T cell subsets (e.g. Th1, Th17, and Treg), CD8+ T cells, monocytes, dendritic cells, and mast cells. Due to alternative splicing, CD366 exists as membrane-bound and soluble forms. Galectin-9 has been identified as the ligand for CD366. In humans, this receptor negatively regulates CD4+ T cells, influencing the secretion of some Th1- and Th17-related cytokines. CD366 has also been implicated in tolerance, autoimmune disease (e.g. multiple sclerosis), and HIV infection.

Details
Host Mouse
Isotype IgG1, kappa
Reactivity Human
Conjugate Super Bright 436
Laser Violet Laser
Emit 436 nm
Excite 405 nm
Legal Patent pending.
Reported Applications Flow Cytometric Analysis
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
12-3109 Anti-Human CD366 (TIM3) PE 488 - 561 nm 578 nm FC RUO
47-3109 Anti-Human CD366 (TIM3) APC-eFluor® 780 633 - 647 nm 780 nm FC RUO
25-3109 Anti-Human CD366 (TIM3) PE-Cyanine7 488 - 561 nm 775 nm FC RUO
48-3109 Anti-Human CD366 (TIM3) eFluor® 450 405 nm 445 nm FC RUO
16-3109 Anti-Human CD366 (TIM3) Functional Grade Purified FA RUO
11-3109 Anti-Human CD366 (TIM3) FITC 488 nm 520 nm FC RUO
17-3109 Anti-Human CD366 (TIM3) APC 633 - 647 nm 660 nm FC RUO
46-3109 Anti-Human CD366 (TIM3) PerCP-eFluor® 710 488 nm 710 nm FC RUO
Related Products
Cat. No. Name Excite Emit Application Reg.
00-6993 7-AAD Viability Staining Solution FC GPR
16-0037 Anti-Human CD3 Functional Grade Purified FC, FA RUO
62-4714 Mouse IgG1 K Isotype Control Super Bright 436 405 nm 436 nm FC RUO
11-0199 Anti-Human CD19 FITC 488 nm 520 nm FC RUO
16-0289 Anti-Human CD28 Functional Grade Purified FC, FA RUO
SB-4400 Super Bright Staining Buffer FC GPR
References

References: Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA, Kuchroo VK. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol. 2009 Sep;39(9):2492-501. (F38-2E2, FC, PubMed)

Su EW, Lin JY, Kane LP. TIM-1 and TIM-3 proteins in immune regulation. Cytokine. 2008 Oct;44(1):9-13.

Koguchi K, Anderson DE, Yang L, O'Connor KC, Kuchroo VK, Hafler DA. Dysregulated T cell expression of TIM3 in multiple sclerosis. J Exp Med. 2006 Jun 12;203(6):1413-8.