Anti-Human TIM3 eFluor® 450

Description: This F38-2E2 monoclonal antibody reacts with human T cell immunoglobulin and mucin domain-containing molecule (TIM)-3. The cell surface receptor is expressed on activated CD4+ T cell subsets (e.g. Th1, Th17, and Tregs), CD8+ T cells, monocytes, dendritic cells, and mast cells. Due to alternative splicing, TIM3 exists as membrane-bound and soluble forms. Galectin-9 has been identified as the ligand for TIM3. In humans, this receptor negatively regulates CD4+ T cells, influencing the secretion of some Th1- and Th-17-related cytokines. TIM3 has also been implicated in tolerance, autoimmune disease (e.g. multiple sclerosis), and HIV infection.

References: Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA, Kuchroo VK. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol. 2009 Sep;39(9):2492-501. (F38-2E2, FC, PubMed)

Su EW, Lin JY, Kane LP. TIM-1 and TIM-3 proteins in immune regulation. Cytokine. 2008 Oct;44(1):9-13.

Koguchi K, Anderson DE, Yang L, O'Connor KC, Kuchroo VK, Hafler DA. Dysregulated T cell expression of TIM3 in multiple sclerosis. J Exp Med. 2006 Jun 12;203(6):1413-8.