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Anti-Human TIGIT PE

Also known as: VSTM3, WUCAM

Clone: MBSA43

RUO: For Research Use Only. Not for use in diagnostic procedures.

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SKU# 12-9500

Cat. No. Size
12-9500-41 25 tests
12-9500-42 100 tests

Data for Anti-Human TIGIT PE.

Staining of normal human peripheral blood cells with Anti-Human CD4 APC (cat. 17-0049), Anti-Human...View More

  • Data for Anti-Human TIGIT PE.
Description

Description: The MBSA43 monoclonal antibody reacts with human T cell immunoreceptor with Ig and ITIM domains (TIGIT), which is also known as VSTM3 or WUCAM. This 26 kDa protein is a member of the poliovirus receptor (PVR) family. The expression of TIGIT has been reported on NK cells, regulatory T cells, follicular T helper cells, memory CD4+ T cells, and CD8+ T cells, but it is not expressed on B cells or naïve CD4+ T cells. TIGIT may be upregulated on naïve CD4+ T cells upon activation. TIGIT can interact with certain members of the PVR and PVR-like families, including CD155, and also mediates the interaction of NK and T cells with antigen presenting cells, fibroblasts, and endothelial cells that express PVR and PVR-like proteins.

MBSA43 is reported to crossreact with Rhesus macaque.

Details
Host Mouse
Isotype IgG1, kappa
Reactivity Human
Conjugate PE
Laser Blue Laser, Green Laser, Yellow-Green Laser
Emit 578 nm
Excite 488 - 561 nm
Reported Applications Flow Cytometric Analysis
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
25-9500 Anti-Human TIGIT PE-Cyanine7 488 - 561 nm 775 nm FC RUO
16-9500 Anti-Human TIGIT Functional Grade Purified FC, FA RUO
17-9500 Anti-Human TIGIT APC 633 - 647 nm 660 nm FC RUO
11-9500 Anti-Human TIGIT FITC 488 nm 520 nm FC RUO
48-9500 Anti-Human TIGIT eFluor® 450 405 nm 445 nm FC RUO
46-9500 Anti-Human TIGIT PerCP-eFluor® 710 488 nm 710 nm FC RUO
Related Products
Cat. No. Name Excite Emit Application Reg.
12-4714 Mouse IgG1 K Isotype Control PE 488 - 561 nm 578 nm FC RUO
46-0457 Anti-Human CD45RO PerCP-eFluor® 710 488 nm 710 nm FC RUO
11-4776 Anti-Human Foxp3 FITC 488 nm 520 nm FC, IHC RUO
17-0049 Anti-Human CD4 APC 633 - 647 nm 660 nm FC RUO
References

References: Chew GM, Fujita T, Webb GM, Burwitz BJ, Wu HL, Reed JS, Hammond KB, Clayton KL, Ishii N, Abdel-Mohsen M, Liegler T, Mitchell BI, Hecht FM, Ostrowski M, Shikuma CM, Hansen SG, Maurer M, Korman AJ, Deeks SG, Sacha JB, Ndhlovu LC. TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection. PLoS Pathog. 2016 Jan 7;12(1):e1005349.(MBSA43, FC, PubMed)

Rueda CM, Wells CB, Gisslen T, Jobe AH, Kallapur SG, Chougnet CA. Effect of chorioamnionitis on regulatory T cells in moderate/late preterm neonates. Hum Immunol. 2015 Jan;76(1):65-73. (MBSA43, FC, PubMed)

Seth S, Ravens I, Kremmer E, Maier MK, Hadis U, Hardtke S, Förster R, Bernhardt G. Abundance of follicular helper T cells in Peyer's patches is modulated by CD155. Eur J Immunol. 2009 Nov;39(11):3160-70.

Stanietsky N, Simic H, Arapovic J, Toporik A, Levy O, Novik A, Levine Z, Beiman M, Dassa L, Achdout H, Stern-Ginossar N, Tsukerman P, Jonjic S, Mandelboim O. The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17858-63.

Boles KS, Vermi W, Facchetti F, Fuchs A, Wilson TJ, Diacovo TG, Cella M, Colonna M. A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC. Eur J Immunol. 2009 Mar;39(3):695-703.

Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H, Eaton D, Grogan JL. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol. 2009 Jan;10(1):48-57.


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