Human TGF beta 2 Recombinant Protein

Description: Human Transforming Growth Factor-β2 (TGF- β2) is a member of a superfamily of disulfide-linked homodimeric proteins secreted as latent proteins and stored at the cell surface and extracellular matrix. The bioactive TGF-β2 is released from a latent complex by proteolytic processing and conformation changes. TGF-β2 regulates cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. TGF-βs is also involved in embryogenesis, tissue remodeling and wound healing. TGF-β2 has 97% identity at the amino acid level. Functionally, human TGF-β2 can stimulate mouse cells.

References: Fantini MC, Becker C, Tubbe I, Nikolaev A, Lehr HA, Galle P, Neurath MF. TGF-beta – induced Foxp3+ regulatory T cells suppress Th1-mediated experimental colitis. Gut. 2006 May;55(5):671-80.

Peng Y, Laouar Y, Li MO, Green EA, Flavell RA. TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4572-7.

Zheng SG, Gray JD, Ohtsuka K, Yamagiwa S, Horwitz DA. Generation ex vivo of TGF-b-producing regulatory T cells from CD4+CD25- precursors. J Immunol. 2002 Oct 15;169(8):4183-9.

Roberts AB, Sporn MB. Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta). Growth Factors. 1993;8(1):1-9. Review.

Miyazono K, Heldin CH. Structure, function and possible clinical application of transforming growth factor-beta. J Dermatol. 1992 Nov;19(11):644-7.