Human TGF beta 2 Recombinant Protein Carrier-Free

Also known as: Transforming Growth Factor beta 2, TGFb2

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 34-8478

Cat. No. Size
34-8478-82 100 ug
34-8478-85 500 ug
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Data for Human TGF beta 2 Recombinant Protein Carrier-Free.

Description

Description: Human Transforming Growth Factor beta 2 (TGF beta 2) is a member of a superfamily of disulfide-linked homodimeric proteins secreted as latent proteins and stored at the cell surface and extracellular matrix. The bioactive TGF beta 2 is released from a latent complex by proteolytic processing and conformation changes. TGF beta 2 regulates cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix and is also involved in embryogenesis, tissue remodeling and wound healing.

Details
Reactivity Human
Purity Greater than 98% as measured by SDS-PAGE.
Molecular Mass 25 kDa
Reported Applications Functional Assays
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
14-8478 Human TGF beta 2 Recombinant Protein FA RUO
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References

References: Fantini MC, Becker C, Tubbe I, Nikolaev A, Lehr HA, Galle P, Neurath MF. TGF-beta – induced Foxp3+ regulatory T cells suppress Th1-mediated experimental colitis. Gut. 2006 May;55(5):671-80.

Peng Y, Laouar Y, Li MO, Green EA, Flavell RA. TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4572-7.

Zheng SG, Gray JD, Ohtsuka K, Yamagiwa S, Horwitz DA. Generation ex vivo of TGF-b-producing regulatory T cells from CD4+CD25- precursors. J Immunol. 2002 Oct 15;169(8):4183-9.

Roberts AB, Sporn MB. Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta). Growth Factors. 1993;8(1):1-9. Review.

Miyazono K, Heldin CH. Structure, function and possible clinical application of transforming growth factor-beta. J Dermatol. 1992 Nov;19(11):644-7.